Abstract:Objective To study the correlation between the bronchial dilation test (BDT) and asthma control level in children with asthma. Methods A total of 153 children with asthma, aged 5-14 years, who attended the outpatient service from March 2016 to March 2018 were enrolled. According to the presence or absence of atopic constitution, they were divided into an allergic group with 79 children and a non-allergic group with 74 children. The correlation between BDT and Childhood Asthma Control Test (C-ACT) scores was analyzed for both groups. Results All basic pulmonary function parameters were positively correlated with C-ACT scores in the non-allergic group (P < 0.05). Except the forced vital capacity, peak expiratory flow and maximal expiratory flow at 25% vital capacity in percent predicted values, the other pulmonary function parameters were positively correlated with C-ACT scores in the allergic group (P < 0.05). The improvement rates of all BDT parameters (except maximal expiratory flow at 25% vital capacity in the allergic group and maximal expiratory flow at 50% vital capacity in the non-allergic group) were negatively correlated with C-ACT scores in the two groups (P < 0.05). Conclusions The improvement rate of BDT is well correlated with C-ACT scores in children with asthma, suggesting that BDT can be used as an index for predicting asthma control level.
LIU Xin,FENG Yong,SHANG Yun-Xiao. Correlation between bronchial dilation test and asthma control level in children with asthma[J]. CJCP, 2021, 23(3): 265-270.
Liu AH, Zeiger RS, Sorkness CA, et al. The childhood asthma control test:retrospective determination and clinical validation of a cut point to identify children with very poorly controlled asthma[J]. J Allergy Clin Immunol, 2010, 126(2):267-273, 273.e1.
Global Initiative for Asthma. 2020 GINA report, global strategy for asthma management and prevention[EB/OL].[2020-08-08]. https://ginasthma.org/gina-reports.
[6]
Arakawa H, Hamasaki Y, Kohno Y, et al. Japanese guidelines for childhood asthma 2017[J]. Allergol Int, 2017, 66(2):190-204.
[7]
Fernandes AL, Amorim MM, Caetano LB, et al. Bronchodilator response as a hallmark of uncontrolled asthma:a randomised clinical trial[J]. J Asthma, 2014, 51(4):405-410.
[8]
Galant SP, Morphew T, Newcomb RL, et al. The relationship of the bronchodilator response phenotype to poor asthma control in children with normal spirometry[J]. J Pediatr, 2011, 158(6):953-959.e1.
Liu AH, Zeiger R, Sorkness C, et al. Development and cross-sectional validation of the Childhood Asthma Control Test[J]. J Allergy Clin Immunol, 2007, 119(4):817-825.
[13]
Ismaila AS, Sayani AP, Marin M, et al. Clinical, economic, and humanistic burden of asthma in Canada:a systematic review[J]. BMC Pulm Med, 2013, 13(1):70.
[14]
Ko FS, Leung TF, Hui DC, et al. Asthma Control Test correlates well with the treatment decisions made by asthma specialists[J]. Respirology, 2009, 14(4):559-566.
[15]
Deschildre A, Pin I, El Abd K, et al. Asthma control assessment in a pediatric population:comparison between GINA/NAEPP guidelines, Childhood Asthma Control Test (C-ACT), and physician's rating[J]. Allergy, 2014, 69(6):784-790.
Global Initiative for Asthma. Global strategy for asthma management and prevention:revised 2014[EB/OL].[2020-08-08]. https://ginasthma.org/wp-content/uploads/2019/01/2014-GINA.pdf.
[20]
Global Initiative for Asthma. Global strategy for asthma management and prevention:revised 2018[EB/OL].[2020-08-08]. https://ginasthma.org/wp-content/uploads/2019/01/2018-GINA.pdf.
[21]
Papadopoulos NG, Arakawa H, Carlsen KH, et al. International consensus on (ICON) pediatric asthma[J]. Allergy, 2012, 67(8):976-997.