Abstract：Objective To systematically evaluate the association of early nutrition intake with the risk of bronchopulmonary dysplasia (BPD). Methods PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, Wanfang Data, and Weipu Periodical Database were searched for the observational studies on the association between early nutrition intake and BPD. RevMan 5.3 software was used to perform a Meta analysis of eligible studies. Results Eight observational studies were included, with 548 infants with BPD and 522 infants without BPD. The Meta analysis showed that the BPD group had a significantly lower caloric intake than the non-BPD group within the first week after birth and in the first 2 weeks after birth (P < 0.05). The BPD group had a significantly lower enteral nutrition intake than the non-BPD group (WMD=-18.27, 95%CI:-29.70 to -6.84, P < 0.05), as well as a significantly lower intake of carbohydrate, fat, and protein (P < 0.05). The BPD group had a significantly longer duration of parenteral nutrition than the non-BPD group (WMD=14.26, 95%CI:13.26-15.25, P < 0.05). Conclusions Early nutrition deficiency may be associated with the development of BPD, and more attention should be paid to enteral feeding of infants at a high risk of BPD to achieve total enteral feeding as soon as possible.
FANG Ling-Yu,CHEN Dong-Mei,HAN Shu-Ping et al. Association of early nutrition deficiency with the risk of bronchopulmonary dysplasia: a Meta analysis[J]. CJCP, 2021, 23(4): 390-396.
Stoll BJ, Hansen NI, Bell EF, et al. Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network[J]. Pediatrics, 2010, 126(3):443-456.
Al-Jebawi Y, Agarwal N, Groh Wargo S, et al. Low caloric intake and high fluid intake during the first week of life are associated with the severity of bronchopulmonary dysplasia in extremely low birth weight infants[J]. J Neonatal Perinatal Med, 2020, 13(2):207-214.
Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0[EB/OL].[2020-10-31]. https://training.cochrane.org/handbook/archive/v5.1.
Ding L, Wang HW, Geng HF, et al. Prediction of bronchopulmonary dysplasia in preterm infants using postnatal risk factors[J]. Front Pediatr, 2020, 8:349.
[8]
Gaio P, Verlato G, Daverio M, et al. Incidence of metabolic bone disease in preterm infants of birth weight <1250 g and in those suffering from bronchopulmonary dysplasia[J]. Clin Nutr ESPEN, 2018, 23:234-239.
[9]
Alshaikh B, Buddhavarapu S, Akierman A, et al. Impact of calorie intakes on the risk of bronchopulmonary dysplasia in extremely preterm infants[J]. Arch Pulmonol Respir Care, 2017, 3(1):20-24.
[10]
Lehtinen A, Korhonen P, Hyödynmaa E, et al. Adipokines played a limited role in predicting temporary growth differences between very low birthweight infants with and without bronchopulmonary dysplasia[J]. Acta Paediatr, 2017, 106(10):1583-1588.
Uberos J, Lardón-Fernández M, Machado-Casas I, et al. Nutrition in extremely low birth weight infants:impact on bronchopulmonary dysplasia[J]. Minerva Pediatr, 2016, 68(6):419-426.
[13]
Wilson DC, McClure G, Halliday HL, et al. Nutrition and bronchopulmonary dysplasia[J]. Arch Dis Child, 1991, 66(1 Spec No):37-38.
[14]
Jobe AH, Bancalari E. Bronchopulmonary dysplasia[J]. Am J Respir Crit Care Med, 2001, 163(7):1723-1729.
[15]
Bancalari E, Abdenour GE, Feller R, et al. Bronchopulmonary dysplasia:clinical presentation[J]. J Pediatr, 1979, 95(5 Pt 2):819-823.
Lelijveld N, Kerac M, Seal A, et al. Long-term effects of severe acute malnutrition on lung function in Malawian children:a cohort study[J]. Eur Respir J, 2017, 49(4):1601301.
[18]
Massaro GD, Radaeva S, Clerch LB, et al. Lung alveoli:endogenous programmed destruction and regeneration[J]. Am J Physiol Lung Cell Mol Physiol, 2002, 283(2):L305-L309.
[19]
Joss-Moore LA, Hagen-Lillevik SJ, Yost C, et al. Alveolar formation is dysregulated by restricted nutrition but not excess sedation in preterm lambs managed by noninvasive support[J]. Pediatr Res, 2016, 80(5):719-728.
[20]
Ehrenkranz RA, Das A, Wrage LA, et al. Early nutrition mediates the influence of severity of illness on extremely LBW infants[J]. Pediatr Res, 2011, 69(6):522-529.
[21]
Uberos J, Jimenez-Montilla S, Molina-Oya M, et al. Early energy restriction in premature infants and bronchopulmonary dysplasia:a cohort study[J]. Br J Nutr, 2020, 123(9):1024-1031.
[22]
Klevebro S, Westin V, Stoltz Sjöström E, et al. Early energy and protein intakes and associations with growth, BPD, and ROP in extremely preterm infants[J]. Clin Nutr, 2019, 38(3):1289-1295.
[23]
Mohamed I, Elremaly W, Rouleau T, et al. Oxygen and parenteral nutrition two main oxidants for extremely preterm infants:‘it all adds up’[J]. J Neonatal Perinatal Med, 2015, 8(3):189-197.
