1. Department of Pediatrics, Peking University Third Hospital, Beijing 100191, China；
2. Department of Neonatology, Women and Children's Hospital Affiliated to Xiamen University /Xiamen Maternal and Child Health Hospital, Xiamen, Fujian 361003, China；
3. Department of Neonatology, Pediatric Hospital of Fudan University, Shanghai 201102, China；
4. Department of Clinical Nutrition, Guangzhou Women & Children Medical Center, Guangzhou, Guangdong 510623, China；
5. Department of Neonatology, Children's Medical Center, Second Xiangya Hospital of Central South University, Changsha Hunan 410011, China；
6. Department of Neonatology, BaYi Children's Hospital, Seventh Medical Center of the Chinese people's Liberation Army, Beijing 100700, China
摘要 早产儿代谢性骨病（metabolic bone disease of prematurity，MBDP）是由于机体钙磷代谢紊乱导致骨矿物质含量减少的全身性骨骼疾病。我国目前对MBDP尚缺乏深入研究和系统认识，在临床管理方面存在很多不规范之处。现基于国内外相关研究，采用证据推荐分级的评估、制定与评价方法（Grading of Recommendations Assessment，Development and Evaluation），制定MBDP临床管理专家共识，从MBDP的高危因素、筛查/诊断、预防、治疗及出院后随访等5个方面提出推荐意见，旨在为相关从业人员提供 MBDP临床管理的建议，以减少MBDP的发生及改善其近远期预后。
Abstract：Metabolic bone disease of prematurity (MBDP) is a systemic bone disease with a reduction in bone mineral content due to disorder of calcium and phosphorus metabolism. There is still a lack of in-depth research and systematic understanding of MBDP in China, and there are many irregularities in clinical management of this disease. Based on relevant studies in China and overseas, Grading of Recommendations Assessment, Development and Evaluation was used to develop the expert consensus on the clinical management of MBDP, which provides recommendations from the following five aspects: high-risk factors, screening/diagnosis, prevention, treatment, and post-discharge follow-up of MBDP, so as to provide relevant practitioners with recommendations on the clinical management of MBDP to reduce the incidence rate of MBDP and improve its short- and long-term prognosis.
