超早产儿解脲脲原体感染及定植状态的临床特征分析

doi:10.7499/j.issn.1008-8830.2403002

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摘要目的探讨超早产儿解脲脲原体（Ureaplasma urealyticum, UU）感染及定植状态的临床特征及对支气管肺发育不良（bronchopulmonary dysplasia, BPD）的影响。方法选取2018年9月—2022年9月于深圳市妇幼保健院新生儿科住院的258例超早产儿进行回顾性分析。根据UU核酸检测结果以及UU感染和定植的评估标准，将研究对象分为UU阴性组（155例）、UU感染组（70例）、UU定植组（33例）。比较三组超早产儿的一般资料、主要及次要临床结局。结果与UU阴性组相比，UU感染组BPD的发生率升高（P<0.05），总用氧时间及住院时长延长（P<0.05）；与UU阴性组相比，UU定植组BPD及中重度BPD的发生率比较差异均无统计学意义（P>0.05）。结论 UU对早产儿BPD的影响与UU的致病状态密切相关（即感染或定植），UU感染的超早产儿BPD的发生率明显升高，总用氧时间及住院时长明显延长。UU定植的超早产儿BPD和中重度BPD的发生率无上升。

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	王燕琼
	曾雅丽
	陈雪雨
	黄智峰
	杨传忠

关键词 ：解脲脲原体, 感染, 定植, 临床特征, 超早产儿

Abstract：Objective To investigate the clinical characteristics of Ureaplasma urealyticum (UU) infection and colonization in extremely preterm infants and its impact on the incidence of bronchopulmonary dysplasia (BPD). Methods A retrospective analysis was conducted on 258 extremely preterm infants who were admitted to the Department of Neonatology, Shenzhen Maternity and Child Healthcare Hospital, from September 2018 to September 2022. According to the results of UU nucleic acid testing and the evaluation criteria for UU infection and colonization, the subjects were divided into three groups: UU-negative group (155 infants), UU infection group (70 infants), and UU colonization group (33 infants). The three groups were compared in terms of general information and primary and secondary clinical outcomes. Results Compared with the UU-negative group, the UU infection group had significant increases in the incidence rate of BPD, total oxygen supply time, and the length of hospital stay (P<0.05), while there were no significant differences in the incidence rates of BPD and moderate/severe BPD between the UU colonization group and the UU-negative group (P>0.05). Conclusions The impact of UU on the incidence of BPD in extremely preterm infants is associated with the pathogenic state of UU (i.e., infection or colonization), and there are significant increases in the incidence rate of BPD, total oxygen supply time, and the length of hospital stay in extremely preterm infants with UU infection. UU colonization is not associated with the incidence of BPD and moderate/severe BPD in extremely preterm infants.

Key words： Ureaplasma urealyticum Infection Colonization Clinical charateristic Extremely preterm infant

收稿日期: 2024-03-04

通讯作者: 杨传忠，男，主任医师。Email：yangczgd@163.com。 E-mail: yangczgd@163.com

作者简介: 王燕琼，女，硕士研究生；

引用本文:

王燕琼,曾雅丽,陈雪雨等. 超早产儿解脲脲原体感染及定植状态的临床特征分析[J]. 中国当代儿科杂志, 2024, 26(8): 811-816.

WANG Yan-Qiong,ZENG Ya-Li,CHEN Xue-Yu et al. Clinical characteristics of Ureaplasma urealyticum infection and colonization in extremely preterm infants[J]. CJCP, 2024, 26(8): 811-816.

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