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| 胎盘铁转运蛋白研究进展 |
| 赵晋英，黄泽智，李艳伟 |
| 邵阳医学高等专科学校检验系，湖南邵阳422001 |
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| Research advance on placental iron transport proteins |
| ZHAO Jin-Ying, HUANG Ze-Zhi, LI Yan-Wei |
| Department of Laboratory Medicine, Shaoyang Medical College, Shaoyang 422001,China |
| ［1］Heaton SJ, Eady JJ, Parker ML, Gotts KL, Dainty JR, Fairweather-Tait SJ, et al. The use of BeWo cells as an in vitro model for placental iron transport［J］. Am J Physiol Cell Physiol, 2008, 295(5):C1445-1453.
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| ［2］Li YQ, Yan H, Bai B. Change in iron transporter expression in human term placenta with different maternal iron status［J］. Eur J Obstet Gynecol Reprod Biol, 2008, 140(1):48-54.
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| ［3］Bastin J, Drakesmith H, Rees M, Sargent I, Townsend A. Localisation of proteins of iron metabolism in the human placenta and liver ［J］. Br J Haematol, 2006,134(5):532-543.
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| ［4］Ke Y, Qian ZM. Brain iron metabolism: neurobiology and neurochemistry［J］. Prog Neurobiol, 2007, 83(3):149-173.
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| ［5］Georgieff MK, Wobken JK, Welle J, Burdo JR, Connor JR. Identification and localization of divalent metal transporter-1 (DMT-1) in term human placenta ［J］. Placenta, 2000, 21(8):799-804.
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| ［6］Gruper Y, Bar J, Bacharach E, Ehrlich R. Transferrin receptor co-localizes and interacts with the hemochromatosis factor (HFE) and the divalent metal transporter-1 (DMT1) in trophoblast cells ［J］. J Cell Physiol, 2005, 204(3):901-912.
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| ［7］Gunshin H, Fujiwara Y, Custodio AO, Direnzo C, Robine S, Andrews NC. Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver ［J］. J Clin Invest, 2005, 115(5):1258-1266.
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| ［8］Bradley J, Leibold EA, Harris ZL, Wobken JD, Clarke S, Zumbrennen KB, et al. Influence of gestational age and fetal iron status on IRP activity and iron transporter protein expression in thirdtrimester human placenta ［J］. Am J Physiol Regul Integr Comp Physiol, 2004, 287(4):R894-901.
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| ［9］孔佩艳, 廖清奎, 罗春华, 李钦伯, 李丰益, 符仁义, 等. 铁蛋白在胎盘组织的定位及其在母胎铁转运中的作用 ［J］. 中华血液学杂志, 1997,18(11)：575-576.
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| ［10］Takami M, Mizumoto K, Kasuya I, Kino K, Sussman HH, Tsunoo H. Human placental ferritin receptor ［J］. Biochim Biophys Acta, 1986, 884(1):31-38.
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| ［11］Moroz C, Traub L, Maymon R, Zahalka MA. PLIF, a novel human ferritin subunit from placenta with immunosuppressive activity ［J］. J Biol Chem, 2002, 277(15):12901-12905.
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| ［12］Santambrogio P, Biasiotto G, Sanvito F, Olivieri S, Arosio P, Levi S. Mitochondrial ferritin expression in adult mouse tissues ［J］. J Histochem Cytochem, 2007, 55(11):1129-1137.
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| ［13］Fowler C. Hereditary hemochromatosis: pathophysiology, diagnosis, and management［J］. Crit Care Nurs Clin North Am, 2008, 20(2):191-201.
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| ［14］Parkkila S, Waheed A, Britton RS, Bacon BR, Zhou XY, Tomatsu S, et al. Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis ［J］. Proc Natl Acad Sci U S A, 1997, 94(24):13198-13202.
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| ［15］Donovan A, Brownlie A, Zhou Y, Shepard J, Pratt SJ, Moynihan J, et al. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter ［J］. Nature, 2000, 403(6771):711-713.
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| ［16］Mok H, Mendoza M, Prchal JT, Balogh P, Schumacher A. Dysregulation of ferroportin 1 interferes with spleen organogenesis in polycythaemia mice ［J］. Development, 2004,131(19):4871-4881.
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| ［17］Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalisation ［J］. Science, 2004, 306(5704): 2090-2093.
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| ［18］Millard KN, Frazer DM, Wilkins SJ, Anderson GJ. Changes in the expression of intestinal iron transport and hepatic regulatory molecules explain the enhanced iron absorption associated with pregnancy in the rat ［J］. Gut, 2004, 53(5): 655-660.
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| ［19］Martin ME, Nicolas G, Hetet G, Vaulont S, Grandchamp B, Beaumont C. Transferrin receptor 1 mRNA is downregulated in placenta of hepcidin transgenic embryos ［J］. FEBS Lett, 2004, 574(1-3):187-191.
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| ［20］Danzeisen R, Ponnambalam S, Lea RG, Page K, Gambling L, McArdle HJ. The effect of ceruloplasmin on iron release from placental (BeWo) cells; evidence for an endogenous Cu oxidase ［J］. Placenta, 2000, 21(8):805-812.
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| ［21］Danzeisen R, Fosset C, Chariana Z, Page K, David S, McArdle HJ. Placental ceruloplasmin homolog is regulated by iron and copper and is implicated in iron metabolism ［J］. Am J Physiol Cell Physiol, 2002, 282(3):C472-478.
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| ［22］Petrak J, Vyoral D. Hephaestin—a ferroxidase of cellular iron export ［J］. Int J Biochem Cell Biol, 2005,37(6):1173-1178.
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| ［23］Ghosh MC, Tong WH, Zhang D, Ollivierre-Wilson H, Singh A, Krishna MC, et al. Tempolmediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice［J］. Proc Natl Acad Sci U S A, 2008, 105(33):12028-12033.
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| ［24］Neupert B, Thompson NA, Meyer C, Kühn LC. A high yield affinity purification method for specific RNA-binding proteins: isolation of the iron regulatory factor from human placenta ［J］. Nucleic Acids Res, 1990, 18(1):51-55.
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| ［25］Georgieff MK, Berry SA, Wobken JD, Leibold EA. Increased placental iron regulatory protein-1 expression in diabetic pregnancies complicated by fetal iron deficiency ［J］. Placenta, 1999, 20(1):87-93.
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| ［26］Gambling L, Danzeisen R, Gair S, Lea RG, Charania Z, Solanky N. Effect of iron deficiency on placental transfer of iron and expression of iron transport proteins in vivo and in vitro ［J］. Biochem J, 2001, 356(Pt 3):883-889.
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| ［27］Starreveld JS, van Denderen J, Kroos MJ, van Eijk HG, van Dijk JP. Effects of iron supplementation on iron uptake by differentiating cytotrophoblasts ［J］. Reprod Fertil Dev, 1996, 8(3):417-422.
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| ［28］KeyiKroos MJ, Starreveld JS, Verrijt CE, van Eijk HG, van Dijk JP. Regulation of transferrin receptor synthesis by human cytotrophoblast cells in culture ［J］. Eur J Obstet Gynecol Reprod Biol, 1996, 65(2):231-234.
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| ［29］Petry CD, Wobken JD, McKay H, Eaton MA, Seybold VS, Johnson DE. Placental transferrin receptor in diabetic pregnancies with increased fetal iron demand ［J］. Am J Physiol, 1994, 267(4 Pt 1):E507-514.
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| ［30］Georgieff MK, Petry CD, Mills MM, McKay H, Wobken JD. Increased N-glycosylation and reduced transferrin-binding capacity of transferrin receptor isolated from placentae of diabetic women ［J］. Placenta, 1997, 18(7):563-568.
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| ［31］廖清奎，罗春华，李强.胎盘转铁蛋白受体对调节母婴铁代谢的作用［J］.中华医学杂志, 1992, 72(10):619-621, 640.
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| ［32］Liao QK, Kong PA, Gao J, Li FY, Qian ZM. Expression of ferritin receptor in placental microvilli membrane in pregnant women with different iron status at mid-term gestation ［J］. Eur J Clin Nutr, 2001, 55(8):651-656.
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| ［33］Verrijt CE, Kroos MJ, Huijskes-Heins MI, van Eijk HG, van Dijk JP. Non-transferrin iron uptake by trophoblast cells in culture. Significance of a NADH-dependent ferrireductase ［J］. Placenta, 1998, 19(7):525-530.
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| ［34］Renegar RH, Bazer FW, Roberts RM. Placental transport and distribution of uteroferrin in the fetal pig ［J］. Biol Reprod, 1982, 27(5):1247-1260.
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| ［35］Leitner K, Ellinger A, Zimmer KP, Ellinger I, Fuchs R. Localization of beta 2-microglobulin in the term villous syncytiotrophoblast ［J］. Histochem Cell Biol, 2002, 117(2):187-193.
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赵晋英, 黄泽智, 李艳伟. 胎盘铁转运蛋白研究进展[J]. 中国当代儿科杂志, 2009, 11(06): 510-513. |
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