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Clinical features of asymptomatic or subclinical COVID-19 in children
LIU You-Jing, CHEN Peng, LIU Zhi-Sheng, LI Ying, DU Hui, XU Jia-Li
Chinese Journal of Contemporary Pediatrics ›› 2020, Vol. 22 ›› Issue (6) : 578-582.
PDF(1423 KB)
PDF(1423 KB)
Clinical features of asymptomatic or subclinical COVID-19 in children
Objective To study the clinical features of asymptomatic or subclinical coronavirus disease 2019 (COVID-19) in children. Methods A retrospective analysis was performed for the clinical data of 53 children who were confirmed with asymptomatic or subclinical COVID-19, including epidemiological history, clinical typing, co-infection, time to clearance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid in nasopharyngeal swabs, laboratory examination results, length of hospital stay, and treatment outcome. Results The children with asymptomatic or subclinical COVID-19 accounted for 30.5% (53/174) in children with COVID-19 hospitalized in the COVID-19 ward of Wuhan Children's Hospital. All cases occurred with familial aggregation. Among the 53 children, 35 (66%) had asymptomatic infection and 18 (34%) had subclinical infection. Mycoplasma infection was found in 17 children (32%). For the 53 children, the mean time to clearance of SARS-CoV-2 nucleic acid in nasopharyngeal swabs was 9±4 days. Most laboratory markers were maintained within the normal range. The mean hospital stay was 11±4 days. Lung CT of 18 children with subclinical COVID-19 showed ground-glass opacities, linear opacities, and patchy opacities, with relatively limited lesions. Conclusions There is a high proportion of children with asymptomatic or subclinical COVID-19 among the children with COVID-19 hospitalized in the COVID-19 ward. The transmission risk of asymptomatic or subclinical COVID-19 should be taken seriously.
COVID-19 / Severe acute respiratory syndrome coronavirus 2 / Asymptomatic infection / Subclinical infection / Clinical feature / Child
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