Abstract Objective To study the clinical significance of anti-endothelial cell antibodies (AECA) and antineutrophil cytoplasmic antibodies (ANCA) in Kawasaki disease (KD) and its complication of coronary arterial lesions (CAL). Methods Forty-two children with KD, as well as 20 children with fever caused by respiratory infection (fever control group) and 15 children for selective operation (normal control group), were included in the study. Serum levels of AECA and ANCA were measured using enzyme-linked immunosorbent assay. Echocardiography was performed to evaluate CAL in KD patients. Results During the acute phase, the KD patients had significantly higher serum AECA and ANCA levels than the two control groups (PPPPr=0.88, PConclusions AECA and ANCA may be involved in vasculitis and CAL among children with KD. Serum levels of AECA and ANCA may be used as indicators for the diagnosis of suspected KD cases in the acute phase. Elevated ANCA level has a certain predictive value for CAL.
ZHAO Jian-Mei,WANG Xiao-Hua. Clinical significance of anti-neutrophil cytoplasmic antibodies and anti-endothelial cell antibodies in children with Kawasaki disease[J]. CJCP, 2014, 16(7): 740-744.
ZHAO Jian-Mei,WANG Xiao-Hua. Clinical significance of anti-neutrophil cytoplasmic antibodies and anti-endothelial cell antibodies in children with Kawasaki disease[J]. CJCP, 2014, 16(7): 740-744.
Guilpain P, Mouthon L. Antiendothelial cells autoantibodies in vasculitis-associated systemic diseases[J]. Clin Rev Allergy Immunol, 2008, 35(1-2): 59-65.
[2]
Hagen EC, Daha MR, Hermans J, et al. Diagnostic value of standardized assays for anti-neutrophil cytoplasmic antibodies in idiopathic systemic vasculitis. EC/BCR Project for ANCA Assay Standardization[J]. Kidney Int, 1998, 53(3):743-753.
[3]
Japaness Circulation Society Joint Research Group. Guidelines for diagnosis and management of cardiovascular sequelae in Kawasaki disease[J]. Pediatr Int, 2005, 47(6): 711-732.
[4]
Belay ED, Maddox RA, Holman RC, et al. Kawasaki syndrome and risk factors for coronary artery abnormalities: United States, 1994-2003[J]. Pediatr Infect Dis J, 2006, 25(3): 245-249.
Kobayashi S, Fujimoto S, Takahashi K, et al. Anti-neutrophil cytoplasmic antibody-associated vasculitis, large vessel vasculitis and Kawasaki disease in Japan[J]. Kidney Blood Press Res, 2010, 33(6): 442-455.
[7]
Kuo HC, Yu HR, Juo SH, et al. CASP3 gene single-nucleotide polymorphism (rs72689236) and Kawasaki disease in Taiwanese children[J]. J Hum Genet, 2011, 56(2): 161-165.
[8]
Newburger JW, Takahashi M, Gerber MA, et al. Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association[J]. Circulation, 2004, 110(17): 2747-2771.
[9]
Grunebaum E, Blank M, Cohen S, et al. The role of antiendothelial cell antibodies in Kawasaki disease-in vitro and in vivo studies[J]. Clin Exp Immunol, 2002, 130(2): 233-240.
[10]
Karasawa R, Fujieda M, Yudoh K. Detection of specific markers: our research on the marker in patients with Kawasaki disease[J]. Nihon Rinsho Meneki Gakkai Kaishi, 2010, 33(4): 207-213.
[11]
Lin YS, Lin CF, Lei HY, et al. Antibody-mediated endothelial cell damage via nitric oxide[J]. Curr Pharm Des, 2004, 10(2): 213-221.
