Research advances in association between vitamin D and Kawasaki disease and related mechanisms of action

YANG Xue; DONG Xiang-Yu

doi:10.7499/j.issn.1008-8830.2016.12.024

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Chinese Journal of Contemporary Pediatrics ›› 2016, Vol. 18 ›› Issue (12) : 1319-1323. DOI: 10.7499/j.issn.1008-8830.2016.12.024

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Research advances in association between vitamin D and Kawasaki disease and related mechanisms of action

YANG Xue, DONG Xiang-Yu

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Abstract

Vitamin D is an important steroid hormone, which has a wide biological effect and is the protective factor against cardiovascular disease and other diseases. At present, the etiology and pathogenesis of Kawasaki disease (KD) remain unknown, but recent studies have shown that vitamin D insufficiency or deficiency is associated with KD. Vitamin D insufficiency or deficiency may affect KD via its influence on inflammatory response, adipokine, endothelial function, platelet function, and DNA methylation and increase the risk of coronary artery lesions. This article reviews the research advances in the association between vitamin D and KD and possible mechanisms of action.

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Vitamin D / Kawasaki disease / Inflammatory response

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YANG Xue, DONG Xiang-Yu. Research advances in association between vitamin D and Kawasaki disease and related mechanisms of action[J]. Chinese Journal of Contemporary Pediatrics. 2016, 18(12): 1319-1323 https://doi.org/10.7499/j.issn.1008-8830.2016.12.024

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