Risk factors associated with the need for mechanical ventilation in children with Guillain-Barré syndrome

LI Cheng; SUN Rui-Di; FENG Li; JIANG Jun

doi:10.7499/j.issn.1008-8830.2106003

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Chinese Journal of Contemporary Pediatrics ›› 2021, Vol. 23 ›› Issue (9) : 922-926. DOI: 10.7499/j.issn.1008-8830.2106003

CLINICAL RESEARCH

Risk factors associated with the need for mechanical ventilation in children with Guillain-Barré syndrome

LI Cheng, SUN Rui-Di, FENG Li, JIANG Jun

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Abstract

Objective To study the risk factors associated with the need for mechanical ventilation in children with Guillain-Barré syndrome (GBS). Methods The medical data of 107 children with GBS were retrospectively reviewed. According to whether mechanical ventilation was required, the children were divided into a mechanical ventilation group with 16 children and a non-mechanical ventilation group with 91 children. The risk factors associated with the need for mechanical ventilation in children with GBS were identified by a multivariate logistic regression analysis. Results Among the 107 children, 16 (15.0%) required mechanical ventilation. Compared with the non-mechanical ventilation group, the mechanical ventilation group had a significantly higher proportion of children with facial and/or bulbar muscle weakness, a significantly shorter duration from the onset to the peak of the disease, and a significantly higher Hughes Functional Grading Scale score at the first visit (P<0.05). Facial and/or bulbar muscle weakness and short duration from the onset to the peak of the disease were risk factors associated with the need for mechanical ventilation in children with GBS (OR=5.053 and 1.239 respectively, P<0.05). Conclusions Facial and/or bulbar muscle weakness and short duration from the onset to the peak of the disease may increase the risk of mechanical ventilation in children with GBS. Citation:

Key words

Guillain-Barre syndrome / Mechanical ventilation / Child

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LI Cheng, SUN Rui-Di, FENG Li, JIANG Jun. Risk factors associated with the need for mechanical ventilation in children with Guillain-Barré syndrome[J]. Chinese Journal of Contemporary Pediatrics. 2021, 23(9): 922-926 https://doi.org/10.7499/j.issn.1008-8830.2106003

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