Recent research on tofacitinib in the treatment of pediatric rheumatic diseases

ZHOU Shi-Hai; XIONG Ya-Qun; CHEN Ya

doi:10.7499/j.issn.1008-8830.2201081

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Chinese Journal of Contemporary Pediatrics ›› 2022, Vol. 24 ›› Issue (4) : 447-453. DOI: 10.7499/j.issn.1008-8830.2201081

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Recent research on tofacitinib in the treatment of pediatric rheumatic diseases

ZHOU Shi-Hai, XIONG Ya-Qun, CHEN Ya

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Abstract

Tofacitinib is a Janus kinase inhibitor and can block the Janus kinase-signal transducer and activator of transcription signal transduction pathway and reduce the production and release of a variety of cytokines. It has great potential in the treatment of various rheumatic diseases with a rapid onset of action and can reduce corticosteroid dependence and related adverse events. The therapeutic effect of tofacitinib in adult patients has been confirmed, and it has been increasingly used in pediatric patients in recent years. This article reviews the clinical application of tofacitinib in the treatment of pediatric autoimmune diseases.

Key words

Rheumatic disease / Janus kinase-signal transducer and activator of transcription signaling pathway / Tofacitinib / Child

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ZHOU Shi-Hai, XIONG Ya-Qun, CHEN Ya. Recent research on tofacitinib in the treatment of pediatric rheumatic diseases[J]. Chinese Journal of Contemporary Pediatrics. 2022, 24(4): 447-453 https://doi.org/10.7499/j.issn.1008-8830.2201081

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