Diagnosis and treatment of human monkeypox

YAO Kai-Hu, DU Qian-Qian, HU Ya-Hong

Chinese Journal of Contemporary Pediatrics ›› 2022, Vol. 24 ›› Issue (9) : 960-966.

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Chinese Journal of Contemporary Pediatrics ›› 2022, Vol. 24 ›› Issue (9) : 960-966. DOI: 10.7499/j.issn.1008-8830.2207088
TOPIC OF EPIDEMIC PREVENTION AND CONTROL

Diagnosis and treatment of human monkeypox

  • YAO Kai-Hu, DU Qian-Qian, HU Ya-Hong
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Abstract

The guideline for the diagnosis and treatment of monkeypox (2022 edition) issued by National Health Commission of the People's Republic of China introduces the key knowledge of the diagnosis and treatment of human monkeypox (HMPX) and does not systematically introduce the sampling methods and requirements of specimens for HMPX etiology testing and the discrepancy in diagnostic criteria between China and overseas. However, the doctors who are not engaged in dermatology lack understanding of the sampling methods and requirements of specimens for laboratory diagnosis of HMPX, and there are few relevant references available. This article collects the information on the diagnosis and treatment of HMPX, so as to provide a reference for learning, understanding, and application of this guideline. Citation:Chinese Journal of Contemporary Pediatrics, 2022, 24(9): 960-966

Key words

Human monkeypox / Diagnosis / Treatment

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YAO Kai-Hu, DU Qian-Qian, HU Ya-Hong. Diagnosis and treatment of human monkeypox[J]. Chinese Journal of Contemporary Pediatrics. 2022, 24(9): 960-966 https://doi.org/10.7499/j.issn.1008-8830.2207088

References

1 Centers for Disease Control and Prevention. 2022 monkeypox outbreak global map[EB/OL]. (2022-07-28)[2022-07-29]. https://www.cdc.gov/poxvirus/monkeypox/response/2022/world-map.html.
2 World Health Organization. WHO Director-General's statement at the press conference following IHR Emergency Committee regarding the multi-country outbreak of monkeypox - 23 July 2022[EB/OL]. (2022-07-23)[2022-07-26]. https://www.who.int/director-general/speeches/detail/who-director-general-s-statement-on-the-press-conference-following-IHR-emergency-committee-regarding-the-multi--country-outbreak-of-monkeypox--23-july-2022.
3 中华人民共和国国家卫生健康委员会医政医管局. 关于印发猴痘诊疗指南(2022年版)的通知: 国卫办医函〔2022〕202号[EB/OL]. (2022-06-14)[2022-06-16]. http://www.nhc.gov.cn/yzygj/s7653p/202206/d687b12fe8b84bbfaede2c7a5ca596ec.shtml.
4 Centers for Disease Control and Prevention. Specimen collection[EB/OL]. (2016-12-01)[2022-06-13]. https://www.cdc.gov/smallpox/lab-personnel/specimen-collection/index.html.
5 CarrollKC, PfallerMA. 临床微生物学手册[M]. 王辉, 马筱玲, 钱渊, 等译. 12版. 北京: 中华医学电子音像出版社, 2021: 1770-1781.
6 European Centre for Disease Prevention and Control, World Health Organization European Region. Joint ECDC-WHO regional office for Europe monkeypox surveillance bulletin[EB/OL]. (2022-07-20)[2022-07-27]. https://monkeypoxreport.ecdc.europa.eu/.
7 Hughes CM, Liu L, Davidson WB, et al. A tale of two viruses: coinfections of monkeypox and varicella zoster virus in the Democratic Republic of Congo[J]. Am J Trop Med Hyg, 2020, 104(2): 604-611. PMID: 33289470. PMCID: PMC7866336. DOI: 10.4269/ajtmh.20-0589.
8 澎湃新闻. 中疾控发布: 猴痘防控技术指南(2022版)[EB/OL]. (2022-06-17)[2022-06-18]. https://m.thepaper.cn/baijiahao_18616573.
9 Li Y, Olson VA, Laue T, et al. Detection of monkeypox virus with real-time PCR assays[J]. J Clin Virol, 2006, 36(3): 194-203. PMID: 16731033. DOI: 10.1016/j.jcv.2006.03.012.
10 Centers for Disease Control and Prevention. Test procedure: monkeypox virus generic real-time PCR test[EB/OL]. (2022-06-06)[2022-06-13]. https://www.cdc.gov/poxvirus/monkeypox/pdf/PCR-Diagnostic-Protocol-508.pdf.
11 Li Y, Zhao H, Wilkins K, et al. Real-time PCR assays for the specific detection of monkeypox virus West African and Congo Basin strain DNA[J]. J Virol Methods, 2010, 169(1): 223-227. PMID: 20643162. DOI: 10.1016/j.jviromet.2010.07.012.
12 Huhn GD, Bauer AM, Yorita K, et al. Clinical characteristics of human monkeypox, and risk factors for severe disease[J]. Clin Infect Dis, 2005, 41(12): 1742-1751. PMID: 16288398. DOI: 10.1086/498115.
13 Mbala PK, Huggins JW, Riu-Rovira T, et al. Maternal and fetal outcomes among pregnant women with human monkeypox infection in the Democratic Republic of Congo[J]. J Infect Dis, 2017, 216(7): 824-828. PMID: 29029147. DOI: 10.1093/infdis/jix260.
14 Kupferschmidt K. Why monkeypox is mostly hitting men who have sex with men[J]. Science, 2022, 376(6600): 1364-1365. PMID: 35737802. DOI: 10.1126/science.add5966.
15 Tutu van Furth AM, van der Kuip M, van Els AL, et al. Paediatric monkeypox patient with unknown source of infection, the Netherlands, June 2022[J]. Euro Surveill, 2022, 27(29): 2200552. PMID: 35866435. DOI: 10.2807/1560-7917.ES.2022.27.29.2200552.
16 光明网. 美国确认两例儿童猴痘病例[EB/OL]. (2022-07-23)[2022-07-26]. https://m.gmw.cn/baijia/2022-07/23/1303057180.html.
17 Nguyen PY, Ajisegiri WS, Costantino V, et al. Reemergence of human monkeypox and declining population immunity in the context of urbanization, Nigeria, 2017-2020[J]. Emerg Infect Dis, 2021, 27(4): 1007-1014. PMID: 33756100. PMCID: PMC8007331. DOI: 10.3201/eid2704.203569.
18 Nolen LD, Osadebe L, Katomba J, et al. Extended human-to-human transmission during a monkeypox outbreak in the Democratic Republic of the Congo[J]. Emerg Infect Dis, 2016, 22(6): 1014-1021. PMID: 27191380. PMCID: PMC4880088. DOI: 10.3201/eid2206.150579.
19 Mande G, Akonda I, De Weggheleire A, et al. Enhanced surveillance of monkeypox in Bas-Uélé, Democratic Republic of Congo: the limitations of symptom-based case definitions[J]. Int J Infect Dis, 2022, 122: 647-655. PMID: 35809857. DOI: 10.1016/j.ijid.2022.06.060.
20 World Health Organization. Multi-country monkeypox outbreak: situation update[EB/OL]. (2022-06-27)[2022-07-15]. https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON396.
21 Thornhill JP, Barkati S, Walmsley S, et al. Monkeypox virus infection in humans across 16 countries-April-June 2022[J]. N Engl J Med, 2022. Epub ahead of print. PMID: 35866746. DOI: 10.1056/NEJMoa2207323.
22 Wise J. Monkeypox: new clinical symptoms are identified in confirmed cases[J]. BMJ, 2022, 378: o1845. PMID: 35868644. DOI: 10.1136/bmj.o1845.
23 Johnston SC, Johnson JC, Stonier SW, et al. Cytokine modulation correlates with severity of monkeypox disease in humans[J]. J Clin Virol, 2015, 63: 42-45. PMID: 25600603. DOI: 10.1016/j.jcv.2014.12.001.
24 Petersen E, Kantele A, Koopmans M, et al. Human monkeypox: epidemiologic and clinical characteristics, diagnosis, and prevention[J]. Infect Dis Clin North Am, 2019, 33(4): 1027-1043. PMID: 30981594. DOI: 10.1016/j.idc.2019.03.001.
25 Kumar S, Subramaniam G, Karuppanan K. Human monkeypox outbreak in 2022[J]. J Med Virol, 2022. PMID: 35637363. DOI: 10.1002/jmv.27894. Epub ahead of print.
26 Meyer H, Perrichot M, Stemmler M, et al. Outbreaks of disease suspected of being due to human monkeypox virus infection in the Democratic Republic of Congo in 2001[J]. J Clin Microbiol, 2002, 40(8): 2919-2921. PMID: 12149352. PMCID: PMC120683. DOI: 10.1128/JCM.40.8.2919-2921.2002.
27 里奇曼 DD, 惠特利 RJ, 海登 FG. 临床病毒学(原书第三版)[M]. 陈敬贤, 周荣, 彭涛, 等译. 北京: 科学出版社, 2012: 401-421.
28 Ogoina D, Mohammed A, Yinka-Ogunleye A, et al. A case of suicide during the 2017 monkeypox outbreak in Nigeria[J]. IJID Reg, 2022, 3: 226-227. PMID: 35755463. PMCID: PMC9216383. DOI: 10.1016/j.ijregi.2022.04.004.
29 Taylor L. Monkeypox: WHO to rename disease to prevent stigma[J]. BMJ, 2022, 377: o1489. PMID: 35710105. DOI: 10.1136/bmj.o1489.
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