Recent research on chimeric antigen receptor T cells in children with refractory/relapsed acute lymphoblastic leukemia

WEI Nan; CHEN Tian-Ping

doi:10.7499/j.issn.1008-8830.2210056

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Chinese Journal of Contemporary Pediatrics ›› 2023, Vol. 25 ›› Issue (2) : 210-216. DOI: 10.7499/j.issn.1008-8830.2210056

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Recent research on chimeric antigen receptor T cells in children with refractory/relapsed acute lymphoblastic leukemia

WEI Nan, CHEN Tian-Ping

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Abstract

At present, the treatment of refractory/relapsed acute lymphoblastic leukemia is still in a difficult situation, and even if the intensity of chemotherapy is increased or it is combined with hematopoietic stem cell transplantation, some children may have a poor prognosis and a short survival time. Chimeric antigen receptor T-cell (CAR-T) immunotherapy uses genetically engineered T cells and does not rely on the human leukocyte antigen pathway to recognize tumor-specific antigens, and then CAR-T cells bind to target antigen cells to trigger immune response, thereby exerting a sustained anti-leukemia effect. As the most rapidly developed tumor immunotherapy, major breakthroughs have been made for CAR-T cells in the treatment of various hematological tumors, but there still lacks a comprehensive system for the research, development, and production of CAR-T cells and standardized diagnosis and treatment protocols in China. This article reviews the recent research on CAR-T cells in children with refractory/relapsed acute lymphoblastic leukemia.

Key words

Acute lymphoblastic leukemia / Chimeric antigen receptor T cell / Immunotherapy / Child

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WEI Nan, CHEN Tian-Ping. Recent research on chimeric antigen receptor T cells in children with refractory/relapsed acute lymphoblastic leukemia[J]. Chinese Journal of Contemporary Pediatrics. 2023, 25(2): 210-216 https://doi.org/10.7499/j.issn.1008-8830.2210056

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