Status of iron metabolism and erythropoietic proliferation in children with various genotypes of thalassemia

MAI Hui-Rong, LI Chang-Gang, WANG Ying, SHI Hong-Song, ZHAO Wei-Ling, CHEN Yun-Sheng, CHEN Xiao-Wen

Chinese Journal of Contemporary Pediatrics ›› 2010, Vol. 12 ›› Issue (08) : 602-604.

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Chinese Journal of Contemporary Pediatrics ›› 2010, Vol. 12 ›› Issue (08) : 602-604.
CLINICAL RESEARCH

Status of iron metabolism and erythropoietic proliferation in children with various genotypes of thalassemia

  • MAI Hui-Rong, LI Chang-Gang, WANG Ying, SHI Hong-Song, ZHAO Wei-Ling, CHEN Yun-Sheng, CHEN Xiao-Wen
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Abstract

OBJECTIVE: To study the status of iron metabolism and erythropoietic proliferation in children with various genotypes of thalassemia. METHODS: Serum concentrations of ferritin (SF), transferrin receptor (sTfR) and erythropoietin (EPO) were measured in 158 children with thalassemia. The differences in the concentrations of the three indices among children with different genotypes of thalassemia were compared. The correlations of the hemoglobin level with sereum SF, sTfR and EPO levels were assessed. RESULTS: Among the 158 children with thalassemia, 52(32.9%) were diagnosed with alpha-thalassemia minor, 27(17.1%) with HbH disease, 59(37.4%) with beta-thalassemia minor, 13(8.2%) with beta-thalassemia major, and 7(4.4%) with combining alpha beta thalassemia. The SF levels in children with HbH disease or beta-thalassemia major were significantly higher than those in the other thalassemia groups (P<0.01). The sTfR levels in children with beta-thalassemia major were the highest when compared with those in the other thalassemia groups (P<0.05). The EPO levels in children with beta-thalassemia major were also the highest when compared with those in the other thalassemia groups (P<0.01). There was a negative correlation between hemoglobin and EPO levels in children with HbH disease (r=-0.656, P<0.01) and beta-thalassemia major (r=-0.641; P<0.05). CONCLUSIONS: The status of iron metabolism and erythropoietic proliferation is different in children with different genotypes of thalassemia. A combined measurement of SF, sTfR and EPO may reflect the status of erythropoietic proliferation.[Chin J Contemp Pediatr, 2010, 12 (8):602-604]

Key words

Thalassemia / Serum ferritin / Serum transferrin receptor / Erythropoietin / Child

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MAI Hui-Rong, LI Chang-Gang, WANG Ying, SHI Hong-Song, ZHAO Wei-Ling, CHEN Yun-Sheng, CHEN Xiao-Wen. Status of iron metabolism and erythropoietic proliferation in children with various genotypes of thalassemia[J]. Chinese Journal of Contemporary Pediatrics. 2010, 12(08): 602-604

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