A functional MRI study in ADHD children with impulsivity

LI Fei; LI Bao-Juan; SU Lin-Yan; HU De-Wen; LIU Jun; HE Zhong; ZHOU Shun-Ke

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Chinese Journal of Contemporary Pediatrics ›› 2010, Vol. 12 ›› Issue (1) : 24-28.

CLINICAL RESEARCH

A functional MRI study in ADHD children with impulsivity

LI Fei, LI Bao-Juan, SU Lin-Yan, HU De-Wen, LIU Jun, HE Zhong, ZHOU Shun-Ke

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Abstract

OBJECTIVE: Impulsivity is one of the core symptoms of children with attention deficit hyperactivity disorder (ADHD). In order to understand the neuromechanism of the impulsive behaviors in ADHD children, this study investigated the specific functional areas of the brain by functional MRI. METHODS: The subjects consisted of 10 ADHD children with impulsivity, 7 ADHD children without impulsivity and 9 normal children. A functional MRI examination was performed when the subjects were instructed to finish GO and STOP tasks with the GO-STOP impulsivity paradigm. The MRI data during the two tasks of GO and STOP were averaged and the corresponding activation regions between groups were compared. RESULTS: The data from the GO task revealed that the main activation regions of the normal children included frontal pole (superior frontal gyrus, middle frontal gyrus and medial frontal gyrus); the main activation regions of ADHD children without impulsivity were cerebellum (posterior lobe and anterior lobe bouton) and cingulated gyrus; those of ADHD children with impulsivity were medial globus pallidus and insula. The data from the STOP task showed that the main activation regions of normal children included superior frontal gyrus and middle frontal gyrus; those of ADHD children without impulsivity were middle frontal gyrus and cingulate gyrus; those of ADHD children with impulsivity were uncus and putamen. The activation regions of ADHD children with impulsivity were much fewer than the other two groups. CONCLUSIONS: The behavior of impulsivity-control involves a number of specific functional areas in the cerebral cortex. Compared with normal children, ADHD children without impulsivity have weaker brain function and brain activation, and ADHD children with impulsivity demonstrate much fewer brain activation regions, worse brain function and little awareness of the cerebral cortex.［Chin J Contemp Pediatr, 2010, 12 (1):24-28］

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Impulsivity / Attention deficit hyperactivity disorder / Functional MRI / Child

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LI Fei, LI Bao-Juan, SU Lin-Yan, HU De-Wen, LIU Jun, HE Zhong, ZHOU Shun-Ke. A functional MRI study in ADHD children with impulsivity[J]. Chinese Journal of Contemporary Pediatrics. 2010, 12(1): 24-28

References

［1］石统昆, 武丽杰, 王风华, 孙彩虹，周莓，陈素芬. 不同亚型注意缺陷多动障碍儿童视觉工作记忆研究［J］. 中国妇幼保健, 2008, 23(15):2082-2084.
［2］Rubia K, Halari R, Christakou A, Taylor E. Impulsiveness as a timing disturbance: neurocognitive abnormalities in attention-deficit hyperactivity disorder during temporal processes and normalization with methylphenidate［J］. Philos Trans R Soc Lond B Biol Sci, 2009, 364(1525):1919-1931.
［3］Seidman LJ, Valera EM, Makris N, Monuteaux MC, Boriel DL, Kelkar K, et al. Dorsolateral prefrontal and anterior cingulate cortex volumetric abnormalities in adults with attention-deficit/hyperactivity disorder identified by magnetic resonance imaging［J］. Biol Psychiatry, 2006, 60(10):1071-1080.
［4］李飞, 苏林雁, 耿耀国. Barratt冲动量表用于儿童的信度和效度初步研究［J］. 中国临床心理学杂志, 2006, 14(2):115-117.
［5］Dougherty DM, Mathias CW, Marsh DM, Jagar AA. Laboratory behavioral measures of impulsivity［J］. Behav Res Methods, 2005,37(1):82-90.
［6］刘军, 朱炎, 伍玉枝, 苏林雁. 对立违抗性障碍儿童的脑功能磁共振成像特点［J］. 中南大学学报（医学版）, 2008, 33(7):571-575.
［7］庞高峰, 王苏弘, 马岭, 刘冬柏，陈杰，任艳玲，等. 正常儿童与成人反应抑制功能的fMRI比较研究［J］. 中国医学影像学杂志, 2009，17(1):1-4.
［8］Claes L, Vertommen H, Braspenning N. Psychometric properties of the Dickman Impulsivity Inventory［J］. Pers Individ Dif, 2000, 29(1):27-35.
［9］Horn NR, Dolan M, Elliott R, Deakin JF, Woodruff PW. Response inhibition and impulsivity: an fMRI study［J］. Neuropsychologia, 2003, 41(14):1959-1966.
［10］Bush G, Frazier JA, Rauch SL, Seidman LJ, Whalen PJ, Jenike MA. Anterior cingulate cortex dysfunction in attention-deficit/hyperactivity disorder revealed by fMRI and the Counting Stroop［J］. Biol Psychiatry, 1999, 45(12):1542-1552.
［11］刘登堂, 徐一峰, 凌政, 刘含秋，姚振宇，江开达. 首发精神分裂症患者倒背数字作业的fMRI研究［J］. 上海精神医学, 2004, 16(5):258-262.
［12］伍建林, 何立岩, 张清, 宋清伟. 汉字与英文字形辨认的脑功能磁共振成像初步研究［J］. 中国临床医学影像杂志, 2004, 15(4):181-184.
［13］Cant JS, Goodale MA. Attention to form or surface properties modulates different regions of human occipitotemporal cortex［J］. Cereb Cortex, 2007, 17(3):713-731.
［14］Vaidya CJ, Austin G, Kirkorian G, Ridlehuber HW, Desmond JE, Glover GH, et al. Selective effects of methylphenidate in attention deficit hyperactivity disorder: a functional magnetic resonance study［J］. Proc Natl Acad Sci, 1998, 95(24):14494-14499.
［15］Rubia K, Overmeyer S, Taylor E, Brammer M, Williams SC, Simmons A, et al. Hypofrontality in attention deficit hyperactivity disorder during higher-order motor control: a study with functional MRI［J］. Am J Psychiatry, 1999, 156(6):891-896.
［16］Tamm L, Menon V, Reiss AL. Parietal attentional system aberrations during target detection in adolescents with attention deficit hyperactivity disorder: event-related fMRI evidence［J］.Am J Psychiatry, 2006, 163(6):1033-1043.