Late endothelial function in children with coronary aneurysm due to Kawasaki disease

DUAN Chao; DU Zhong-Dong; WANG Yu; JIA Li-Qun

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Chinese Journal of Contemporary Pediatrics ›› 2011, Vol. 13 ›› Issue (5) : 373-376.

CLINICAL RESEARCH

Late endothelial function in children with coronary aneurysm due to Kawasaki disease

DUAN Chao, DU Zhong-Dong, WANG Yu, JIA Li-Qun

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Abstract

OBJECTIVE: To evaluate the late endothelial function in children with coronary aneurysm due to Kawasaki disease (KD). METHODS: Thirty-one children with coronary aneurysms due to KD who had the disease course for more than 1 year and twenty-one age-matched healthy children were enrolled. Brachial artery endothelium-dependent and -independent flow-mediated dilation (FMD), carotid arterial stiffness index (SI) and intima-media thickness (IMT) were measured by high-frequency ultrasound. RESULTS: There were 9 cases of medium and 22 cases of giant coronary aneurysms in the KD group. Twelve KD patients had evidence of myocardial ischemia. Compared to the normal controls, the endothelium-dependent FMD decreased (P<0.05), the carotid arterial SI increased (P<0.05), and the carotid arterial intima-media thickness increased significantly (P<0.05) in children with coronary aneurysms due to KD. The endothelium-dependent FMD decreased more significantly in 12 KD patients with myocardial ischemia than in those without any evidence of myocardial ischemia (P<0.05).ConclusionsLate endothelial dysfunction exists in children with coronary aneurysms due to KD, especially in those with myocardial ischemia.

Key words

Kawasaki disease / Coronary aneurysm / Endothelium-dependent flow-mediated dilation / Child

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DUAN Chao, DU Zhong-Dong, WANG Yu, JIA Li-Qun. Late endothelial function in children with coronary aneurysm due to Kawasaki disease[J]. Chinese Journal of Contemporary Pediatrics. 2011, 13(5): 373-376

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