Abstract Objective To study the diagnostic values of cerebrospinal concentrations of neopterin (NPT) and S100b for central nervous system infections in children. Methods Enzyme-linked immunosorbent assay was used to determinate the cerebrospinal concentrations of NPT and S100b in children with central nervous system infections and control children. The two groups of children were compared in terms of the two indicators, and the diagnostic values of the two indicators were evaluated by ROC curve analysis. Results Children with viral encephalitis had significantly increased cerebrospinal concentrations of NPT and S100b compared with the control group and children with purulent meningitis (PPConclusions Both NPT and S100b have certain values in the diagnosis of central nervous system infections in children, and S100b is better than NPT.
ZHANG Li-Ya,LI Yan,JIN Mei-Fang. 383Diagnostic values of neopterin and S100b for central nervous system infections in children[J]. CJCP, 2014, 16(4): 380-383.
ZHANG Li-Ya,LI Yan,JIN Mei-Fang. 383Diagnostic values of neopterin and S100b for central nervous system infections in children[J]. CJCP, 2014, 16(4): 380-383.
Schmidt H, Heimann B, Djukic M, et al. Neuropsychological sequelae of bacterial and viral meningitis[J]. Brain, 2006, 129(Pt 2): 333-345.
[2]
Rufa A, Cerase A, Annunziata P, et al. Transient supranuclear paresis of the abduction in viral encephalitis of the brainstem[J]. Neurol Sci, 2010, 31(5): 653-655.
[3]
Cano OD, Neurauter G, Fuchs D, et al. Differential effect of type I and type Ⅱ interferons on neopterin production and amino acid metabolism in human astrocyte-derived cells[J]. Neurosci Lett, 2008, 438(1): 22-25.
[4]
Donato R, Cannon BR, Sorci G, et al. Functions of S100 proteins[J]. Curr Mol Med, 2013, 13(1): 24-57.
[5]
Dale RC, Brilot F, Fagan E, et al. Cerebrospinal fluid neopterin in paediatric neurology: a marker of active central nervous system inflammation[J]. Dev Med Child Neurol, 2009, 51(4): 317-323.
Kawakami Y, Fukunaga Y, Hashimoto K. Changes of neopterin in cerebrospinal fluid and serum in children with meningitis[J]. No To Hattatsu, 1996, 28(1): 23-29.
[10]
Luckheeram RV, Zhou R, Verma AD, et al. CD4(+)T cells: differentiation and functions[J]. Clin Dev Immunol, 2012: 925135.
[11]
Donato R. S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles[J]. Int J Biochem Cell Biol, 2001, 33(7): 637-668.
Wang XK, Zhang HL, Meng FH, et al. Elevated levels of S100B, tau and pNFH in cerebrospinal fluid are correlated with subtypes of Guillain-Barre syndrome[J]. Neurol Sci, 2013, 34(5): 655-661.
[14]
Park JW, Suh GI, Shin HE. Association between cerebrospinal fluid S100B protein and neuronal damage in patients with central nervous system infections[J]. Yonsei Med J, 2013, 54(3): 567-571.
[15]
Zhang H, Qi S, Rao J, et al. Development of a rapid and high-performance chemiluminescence immunoassay based on magnetic particles for protein S100B in human serum[J]. Luminescence, 2013, 28(6): 927-932.
[16]
Cernoch I, Schleicher E, Franek M. Production and analytical characterization of neopterin immunoreagents for biosensor developments[J]. Anal Bioanal Chem, 2011, 399(2): 979-986.
