Relationship between serum zinc levels and attention deficit hyperactivity disorder in children

SUN Gui-Xiang, WANG Bing-Hua, ZHANG Ya-Feng

Chinese Journal of Contemporary Pediatrics ›› 2015, Vol. 17 ›› Issue (9) : 980-983.

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Chinese Journal of Contemporary Pediatrics ›› 2015, Vol. 17 ›› Issue (9) : 980-983. DOI: 10.7499/j.issn.1008-8830.2015.09.019
CLINICAL RESEARCH

Relationship between serum zinc levels and attention deficit hyperactivity disorder in children

  • SUN Gui-Xiang1, WANG Bing-Hua1, ZHANG Ya-Feng2
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Abstract

Objective To study the possible relationship between serum zinc levels and attention deficit hyperactivity disorder (ADHD) in Chinese children.Methods Following a systematic search for case-control studies on the serum zinc levels in Chinese children with ADHD published between 2000 and 2015, a Meta analysis was conducted using Stata 12.0 software.Results A total of 17 studies, including 2 177 children with ADHD and 2 900 normal children, were enrolled. The Meta analysis showed that serum zinc levels in children with ADHD were lower than normal children (SMD=-1.33; 95%CI:-2.22, -0.44; P=0.003). The sensitivity analysis indicated that the results were reliable. Egger's test did not find the existence of publication bias.Conclusions Serum zinc levels may be associated with susceptibility to ADHD in children.

Key words

Attention deficit hyperactivity disorder / Serum zinc / Meta analysis / Child

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SUN Gui-Xiang, WANG Bing-Hua, ZHANG Ya-Feng. Relationship between serum zinc levels and attention deficit hyperactivity disorder in children[J]. Chinese Journal of Contemporary Pediatrics. 2015, 17(9): 980-983 https://doi.org/10.7499/j.issn.1008-8830.2015.09.019

References

[1] 王淑华, 叶彩霞, 黎小. 儿童注意缺陷多动症治疗方法分析[J]. 河北医药, 2012, 34(4):608-609.
[2] 陈晶, 陈燕惠. 儿童注意缺陷多动障碍的病因学研究进展[J]. 中国妇幼健康研究, 2008, 19(5):474-476.
[3] 魏宏伟. 注意缺陷多动障碍儿童血清氨基酸和微量元素系列 的检测及意义[D]. 上海:第二军医大学, 2004.
[4] 张勤, 王欣欣, 朱海峤. 儿童注意缺陷多动障碍与血铅、微 量元素水平关系的探讨[J]. 浙江医学, 2002, 24(9):517-521.
[5] 高铁英, 喻书彻, 史秀兰, 等. 儿童ADHD 视听整合持续操作 测验的诊断意义及与血铅、铁、锌相关研究[J]. 中国儿童保 健杂志, 2005, 13(1):33-34.
[6] Higgins JT, Thompson SG. Quantifying heterogeneity in a metaanalysis[ J]. Stat Med, 2002, 21 (11):1539-1558.
[7] 冯瑞, 邵红梅, 朱红, 等. 妊娠期糖尿病危险因素的Meta 分 析[J]. 中国妇幼保健, 2014, 29(17):2824-2827.
[8] 黄健红, 周才, 司徒坚墉, 等. 儿童注意缺陷多动障碍与微量 元素的关系[J]. 实用医学杂志, 2008, 24(14):2443-2444.
[9] 刘丹莉, 邓晖, 吕建华, 等. 注意缺陷多动障碍与血微量元素 水平的关系[J]. 南华大学学报(医学版), 2008, 36(6):796-798.
[10] 刘洪玉, 郑福兰, 石世同, 等. 云南省4 个民族儿童注意缺陷 多动障碍与血清元素相关性研究[J]. 中国校医, 2006, 20(4):349-351.
[11] 张春玲. 儿童多动症与血微量元素水平的关系探究[J]. 中国 实用医药, 2014, 9(34):87-89.
[12] 阿斯木古丽·克力木, 热依拉·阿不拉, 阿尔祖古丽·牙合 甫. 6-12 岁多动症儿童体内元素水平分析[J]. 中国妇幼保健, 2014, 29(32):5253-5254.
[13] 陈海玲, 唐玉芬, 魏林燕. 儿童末梢血7 种微量元素检测结 果分析[J]. 中国基层医药, 2006, 13(2):307-308.
[14] 董建红, 徐莉莉, 李胜军, 等. 注意缺陷多动障碍儿童体内锌 含量及T 淋巴细胞活性的研究[J]. 中国儿童保健杂志, 2014, 22(9):967-968.
[15] 黄圣元. 多动症患儿血清微量元素水平与行为症状的关系研 究[J]. 中国临床研究, 2015, 28(5):686-688.
[16] 刘静炎. 儿童多动症26 例血锌检测[J]. 郑州大学学报(医学 版), 2003, 38(4):640.
[17] 马兴璇, 龙康, 黄毅勇. 多动症患儿635 例指血微量元素检 测结果分析[J]. 中国民族民间医药, 2014, 12(3):137.
[18] 牟文凤, 宋金莲, 丁伟. 注意缺陷多动障碍儿童体内铅、锌、 铁含量的检测分析[J]. 中国儿童保健杂志, 2013, 21(1):106-108.
[19] 谭美珍, 梁惠慈, 陈力, 等. 儿童多动症与血微量元素水平关 系的探讨[J]. 中国妇幼保健, 2006, 21(3):358-359.
[20] 谭旭, 李廷玉, 梅其霞. 儿童注意缺陷多动障碍与低水平铅 暴露的相关性[J]. 重庆医学大学学报, 2008, 33(5):626-628.
[21] 翟连臣. 门诊儿童6种血清元素临床分析[J].中国药物经济学, 2014, 12(5):102-103.
[22] 刘永春, 李芹. 儿童多动症与微量元素的相关性研究[J]. 实用 临床医药杂志, 2008, 12(4):88-89.
[23] Blomqvist M, Holmbereg K, Lindblad F, et al. Salivary cortisol levels and dental anxiety in children with attention deficit hyperactivity disorder[J]. Eur J Oral Sci, 2007, 115(1):1-6.
[24] Arnold LE, Bozzolo H, Hollway J, et al. Serum zinc correlates with parent and teacher rated in attention in children with attention deficit hyperactivity disorder[J]. Child Adolesc Psychopharmacol, 2005, 15(4):628-636.
[25] Viktorinova A, Ursinyova M, Trebaticka J, et al. Changed plasma levels of zinc and copper to zinc ratio and their possible associations with, parent-and teacher-rated symptoms in children with attention-deficit hyperactivity disorder[J]. Biol Trace Element Res, 2015, 12(7):1021-1027.
[26] Ghanizadeh A, Berk M. Zinc for treating of children and adolescents with attention-deficit hyperactivity disorder:a systematic review of randomized controlled clinical trials[J]. Eur J Clin Nutr, 2013, 67(1):122-124.
[27] 谭利娜, 卫海燕, 张耀东, 等. 血清铁蛋白与儿童注意缺陷多 动障碍关系的 Meta 分析[J]. 中国当代儿科杂志, 2011, 13(9):722-724.
[28] 刘佩意, 让蔚清, 明心海, 等. 国内儿童注意缺陷多动障碍 与血铅水平关系的 Meta 分析[J]. 中华疾病控制杂志, 2014, 18(11):1073-1078.
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