Current status of the application of 1H-magnetic resonance spectroscopy in neonates with hypoxic-ischemic encephalopathy

ZOU Rong; TANG Jun; BAO Shan; WU Tian; HUANG Jing-Lan; QU Yi; MU De-Zhi

doi:10.7499/j.issn.1008-8830.2018.06.004

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Chinese Journal of Contemporary Pediatrics ›› 2018, Vol. 20 ›› Issue (6) : 449-455. DOI: 10.7499/j.issn.1008-8830.2018.06.004

CLINICAL RESEARCH

Current status of the application of ¹H-magnetic resonance spectroscopy in neonates with hypoxic-ischemic encephalopathy

ZOU Rong, TANG Jun, BAO Shan, WU Tian, HUANG Jing-Lan, QU Yi, MU De-Zhi

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Abstract

Objective To investigate the current status of the application of ¹H-magnetic resonance spectroscopy (¹H-MRS) in neonates with hypoxic-ischemic encephalopathy (HIE), and to describe the trend of research in the field. Methods PubMed, EMBASE, and Web of Science were searched for English articles published up to January 10, 2018, with the combination of key words and MeSH terms. The articles were screened according to inclusion and exclusion criteria. Excel 2016, Bicomb 2.0, and VOSviewer1.6.6 were used to analyze the key words, to perform a cluster analysis of hot words, and to plot the knowledge map. Results A total of 66 articles were included, and 27 high-frequency key words were extracted. The results showed that ¹H-MRS was mainly used in four directions of the clinical practice and scientific research on HIE. In clinical practice, ¹H-MRS attracted wide attention as a clinical examination for HIE and a tool for prognostic evaluation; in scientific research, ¹H-MRS was used in animal experiments and studies associated with mild hypothermia therapy. Conclusions As an auxiliary means of magnetic resonance imaging, ¹H-MRS plays an important role in investigating the pathogenesis of neonatal HIE, improving existing therapies, and evaluating the prognosis of neonates with HIE.

Key words

Hypoxic-ischemic encephalopathy / ¹H-magnetic resonance spectroscopy / Co-word analysis / Knowledge map / Neonate

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ZOU Rong, TANG Jun, BAO Shan, WU Tian, HUANG Jing-Lan, QU Yi, MU De-Zhi. Current status of the application of ¹H-magnetic resonance spectroscopy in neonates with hypoxic-ischemic encephalopathy[J]. Chinese Journal of Contemporary Pediatrics. 2018, 20(6): 449-455 https://doi.org/10.7499/j.issn.1008-8830.2018.06.004

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