Research advances in cardiovascular system damage caused by SARS-CoV-2 in children

XIAO Hai-Hui; WANG Xin; XU Yi; WANG Cheng

doi:10.7499/j.issn.1008-8830.2003086

PDF(1172 KB)

Chinese Journal of Contemporary Pediatrics ›› 2020, Vol. 22 ›› Issue (4) : 299-304. DOI: 10.7499/j.issn.1008-8830.2003086

A TOPIC OF CHILDHOOD NOVEL CORONAVIRUS INFECTION

Research advances in cardiovascular system damage caused by SARS-CoV-2 in children

XIAO Hai-Hui, WANG Xin, XU Yi, WANG Cheng

Author information +

History +

Abstract

The outbreak of coronavirus disease 2019 (COVID-19) started in December 2019 in China and the epidemic is still going on at present. Since children are the susceptible population, the number of cases is gradually increasing. In addition to the typical respiratory symptoms, severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) infection also has the clinical symptoms of cardiovascular system damage. Based on a literature review, this article discusses the possible cardiovascular system damage caused by SARS-CoV-2 in children and related mechanisms, in order to provide help for the timely treatment and prevention of cardiovascular system damage caused by SARSCoV-2 in children.

Key words

SARS-CoV-2 / Cardiovascular system / Mechanism / Child

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

XIAO Hai-Hui, WANG Xin, XU Yi, WANG Cheng. Research advances in cardiovascular system damage caused by SARS-CoV-2 in children[J]. Chinese Journal of Contemporary Pediatrics. 2020, 22(4): 299-304 https://doi.org/10.7499/j.issn.1008-8830.2003086

References

[1] Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019[J]. N Engl J Med, 2020, 382(8):727-733.
[2] Gorbalenya AE, Baker SC, Baric RS, et al. Severe acute respiratory syndrome-related coronavirus:the species and its viruses-a statement of the Coronavirus Study Group[J/OL]. BioRxiv. (2020-02-11)[2020-03-05]. https://www.biorxiv.org/content/10.1101/2020.02.07.937862v1.
[3] World Health Organization. WHO Director-General's remarks at the media briefing on 2019-nCoV on 11 February 2020[EB/OL]. (2020-02-11)[2020-03-05]. https://www.who.int/dg/speeches/detail/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020.
[4] 杨斌斌, 朱月玲. 儿童与成人新型冠状病毒肺炎(COVID-19)流行病学与治疗的现状分析[J/OL]. 西安交通大学学报(医学版). (2020-02-18)[2020-03-05]. https://kns.cnki.net/KCMS/detail/61.1399.r.20200216.1319.004.html.
[5] 陈锋, 刘智胜, 张芙蓉, 等. 中国首例儿童危重型新型冠状病毒肺炎[J]. 中华儿科杂志, 2020, 58(3):179-182.
[6] 国家卫生健康委办公厅, 国家中医药管理局办公室. 新型冠状病毒肺炎诊疗方案(试行第七版)[EB/OL]. (2020-03-04)[2020-03-05]. http://www.nhc.gov.cn/xcs/zhengcwj/202003/46c9294a7dfe4cef80dc7f5912eb1989.shtml.
[7] Wu ZY, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019(COVID-19) outbreak in China. Summary of a report of 72314 cases from the Chinese Center for Disease Control and Prevention[J]. JAMA, 2020. DOI:10.1001/jama.2020.2648. Epub ahead of print.
[8] 王端, 鞠秀丽, 谢峰, 等. 中国北方六省(自治区)儿童2019新型冠状病毒感染31例临床分析[J]. 中华儿科杂志, 2020, 58(4):269-274.
[9] de Wilde AH, Snijder EJ, Kikkert M, et al. Host factors in coronavirus replication[J]. Curr Top Microbiol Immunol, 2018, 419:1-42.
[10] 徐宝丽, 管甲亮, 术超, 等. 新型冠状病毒COVID-19相关研究进展[J]. 中华医院感染学杂志, 2020, 30(6):806-811.
[11] Lu R, Zhao X, Li J, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus:implications for virus origins and receptor binding[J]. Lancet, 2020, 395(10224):565-574.
[12] Tang XL, Wu CC, Li X, et al. On the origin and continuing evolution of SARS-CoV-2[J/OL]. Natl Science Rev. (2020-03-03)[2020-03-05]. https://doi.org/10.1093/nsr/nwaa036.
[13] American College of Cardiology. Cardiac implications of novel Wuhan coronavirus (COVID-19)[EB/OL].[2020-03-05]. https://www.acc.org/~/media/Non-Clinical/Files-PDFs-ExcelMS-Word-etc/2020/02/14/S20028-ACC-Clinical-BulletinCoronavirus-FINAL-UPLOADED-Feb-14-2020.pdf.
[14] Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China[J]. Lancet, 2020, 395(10223):497-506.
[15] Wang D, Hu B, Hu C, et al, Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China[J]. JAMA, 2020. DOI:10.1001/jama. 2020.1585. Epub ahead of print.
[16] Yang X, Yu Y, Xu J, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China:a single-centered, retrospective, observational study[J]. Lancet Respir Med, 2020. DOI:10.1016/S2213-2600(20)30079-5. Epub ahead of print.
[17] 姜毅, 陆小霞, 金润铭, 等. 儿童新型冠状病毒感染诊断、治疗和预防专家共识(第二版)[J]. 中华实用儿科临床杂志, 2020, 35(2):143-150.
[18] Cai J, Xu J, Lin D, et al. A case series of children with 2019 novel coronavirus infection:clinical and epidemiological features[J]. Clin Infect Dis, 2020. DOI:10.1093/cid/ciaa198. Epub ahead of print.
[19] 张国勋, 张爱民, 黄丽, 等. 一对双胎女童同时感染新型冠状病毒[J]. 中国当代儿科杂志, 2020, 22(3):221-225.
[20] Xu Z, Shi L, Wang Y, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome[J]. Lancet Respir Med, 2020. DOI:10.1016/S2213-2600(20) 30076-X. Epub ahead of print.
[21] Guan WJ, Ni ZY, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China[J]. N Engl J Med, 2020. DOI:10.1056/NEJMoa2002032. Epub ahead of print.
[22] 徐标, 孙璇. 炎症在心肌损伤和修复中的作用[J]. 临床心血管病杂志, 2018, 34(7):633-635.
[23] 于诗然, 杨旻, 曹新冉, 等. 关注ACE2的心血管保护作用[J]. 中国动脉硬化杂志, 2018, 26(5):433-437.
[24] Mckinney CA, Fattah C, Loughrey CM, et al. Angiotensin-(1-7) and angiotensin-(1-9):function in cardiac and vascular remodelling[J]. Clin Sci, 2014, 126(12):815-827.
[25] Hamming I, Timens W, Bulthuis ML, et al. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis[J]. J Pathol, 2004, 203(2):631-637.
[26] Kuba K, Gao H, Rao S, et al. A crucial role of angiotensin converting enzyme 2(ACE2) in SARS coronavirus-induced lung injury[J]. Nat Med, 2005, 11(8):875-879.
[27] Oudit GY, Kassiri Z, Jiang C, et al. SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS[J]. Eur J Clin Invest, 2009, 39(7):618-625.
[28] Wang Y, Shang J, Graham R, et al. Receptor recognition by novel coronavirus from Wuhan:an analysis based on decadelong structural studies of SARS[J]. J Virol, 2020. DOI:10.1128/JVI.00127-20. Epub ahead of print.
[29] Yan R, Zhang Y, Li Y, et al. Structure of dimeric full-length human ACE2 in complex with B0AT1[J/OL]. BioRxiv. (2020-02-18)[2020-03-15]. https://www.biorxiv.org/content/10.1101/2020.02.17.951848v1.
[30] Morand J, Arnaud C, Pepin JL, et al. Chronic intermittent hypoxia promotes myocardial ischemia-related ventricular arrhythmias and sudden cardiac death[J]. Sci Rep, 2018, 8(1):1-8.
[31] Costanzo MR, Khayat R, Ponikowski P, et al. Mechanisms and clinical consequences of untreated central sleep apnea in heart failure[J]. J Am Coll Cardiol, 2015, 65(1):72-84.
[32] 中华医学会儿科分会心血管学组儿童心肌病精准诊治协作组, 中华医学会儿科分会心血管学组心力衰竭协作组. 新型冠状病毒肺炎防控形势下儿童青少年慢性心力衰竭的临床管理建议[J]. 中华实用儿科临床杂志, 2020, 35(2):112-117.
[33] 刘梦露, 刘华龙, 洪葵. 儿茶酚胺与应激性心肌病发病机制的研究进展[J]. 中国心脏起搏与心电生理杂志, 2019, 33(2):70-72.
[34] Vigneswaran TV, Brown JR, Breuer J, et al. Parvovirus B19 myocarditis in children:an observational study[J]. Arch Dis Child, 2016, 101(2):177-180.
[35] Alhogbani T. Acute myocarditis associated with novel Middle East respiratory syndrome coronavirus[J]. Ann Saudi Med, 2016, 36(1):78-80.
[36] Rao S, Sasser W, Diaz F, et al. Coronavirus associated fulminant myocarditis successfully treated with intravenous immunoglobulin and extracorporeal membrane oxygenation[J]. Chest, 2014, 146(4):336A.
[37] Liu Y, Yang Y, Zhang C, et al. Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury[J]. Sci China Life Sci, 2020, 63(3):364-374.
[38] Din-Dzietham R, Liu Y, Bielo MV, et al. High blood pressure trends in children and adolescents in nation surveys, 1963 to 2002[J]. Circulation, 2007, 116(13):1488-1496.
[39] Ferrario CM, Jessup J, Chappell MC, et al. Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2[J]. Circulation, 2005, 111(20):2605-2610.
[40] 廖玉华, 程翔, 曾秋棠, 等. 湖北省新型冠状病毒肺炎疫情下心血管病治疗与管理专家建议[J]. 临床心血管病杂志, 2020, 36(3):201-203.
[41] 孙美丽, 杨建民, 孙玉萍, 等. RAS抑制剂是治疗新型冠状病毒肺炎的可能选择之一[J]. 中华结核和呼吸杂志, 2020, 43(3):219-222.
[42] 彭昱东, 孟凯, 官红权, 等. 心血管疾病患者感染新型冠状病毒肺炎112例临床特点及转归[J]. 中华心血管杂志, 2020. DOI:10.3760/cma.j.cn112148-20200220-00105. 网络预发表.
[43] 李宏斌, 石珏. 急性左心衰竭合并肺部感染患者血清相关指标检测及其诊断价值[J]. 实用临床医药杂志, 2019, 23(21):54-57.
[44] Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China:a descriptive study[J]. Lancet, 2020, 385(10223):507-513.
[45] Yin HL, Luo CW, Dai ZK, et al. Hypoxia-inducible factor-1α, vascular endothelial growth factor, inducible nitric oxide synthase, and endothelin-1 expression correlates with angiogenesis in congenital heart disease[J]. Kaohsiung J Med Sci, 2016, 32(7):348-355.
[46] 中华医学会儿科学分会. 儿童2019新型冠状病毒感染的诊断与防治建议(试行第一版)[J]. 中华儿科杂志, 2020, 58(3):169-174.