Association between functional dyspepsia and serum levels of brain-gut peptides in children

WANG Dong-Wei; YE Xiao-Lin; WU Jie

doi:10.7499/j.issn.1008-8830.2112029

PDF(526 KB)

Chinese Journal of Contemporary Pediatrics ›› 2022, Vol. 24 ›› Issue (4) : 387-391. DOI: 10.7499/j.issn.1008-8830.2112029

TOPIC OF DIGESTIVE SYSTEM DISEASES

Association between functional dyspepsia and serum levels of brain-gut peptides in children

WANG Dong-Wei, YE Xiao-Lin, WU Jie

Author information +

History +

Abstract

Objective To study the association between functional dyspepsia (FD) and serum levels of brain-gut peptides including calcitonin gene-related peptide (CGRP), nesfatin-1, and ghrelin in children. Method A total of 38 children with FD who attended Shengjing Hospital of China Medical University from November 2019 to December 2020 were enrolled as the FD group. Thirty-four healthy children were enrolled as the control group. Serum samples were collected from all of the children. Enzyme-linked immunosorbent assay was used to measure serum levels of CGRP, ghrelin, and nesfatin-1 for comparison between the two groups. The scores of clinical symptoms were determined for the children with FD. Spearman rank correlation analysis was used to investigate the correlation of symptom scores with the serum levels of brain-gut peptides. Results The FD group had significantly higher serum levels of nesfatin-1 and CGRP than the control group (P<0.05), while there was no significant difference in the serum level of ghrelin between the two groups (P>0.05). The serum level of nesfatin-1 was positively correlated with the symptom score of early satiety (r_s=0.553, P<0.001), but was not significantly correlated with the total score of FD (r_s=0.191, P=0.250). The serum level of CGRP was positively correlated with the scores of abdominal pain (r_s=0.479, P=0.002) and belching (r_s=0.619, P<0.001) and the total score of FD (r_s=0.541, P<0.001). Conclusions CGRP and nesfatin-1 may play an important role in the pathophysiological process of FD.

Key words

Functional dyspepsia / Calcitonin gene-related peptide / Nesfatin-1 / Ghrelin / Child

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

WANG Dong-Wei, YE Xiao-Lin, WU Jie. Association between functional dyspepsia and serum levels of brain-gut peptides in children[J]. Chinese Journal of Contemporary Pediatrics. 2022, 24(4): 387-391 https://doi.org/10.7499/j.issn.1008-8830.2112029

References

1 Ding JH, Jin Z, Yang XX, et al. Role of gut microbiota via the gut-liver-brain axis in digestive diseases[J]. World J Gastroenterol, 2020, 26(40): 6141-6162. PMID: 33177790. PMCID: PMC7596643. DOI: 10.3748/wjg.v26.i40.6141.
2 Butler MI, Cryan JF, Dinan TG. Man and the microbiome: a new theory of everything?[J]. Annu Rev Clin Psychol, 2019, 15: 371-398. PMID: 30786244. DOI: 10.1146/annurev-clinpsy-050718-095432.
3 Liu J, Li F, Tang XD, et al. XiangshaLiujunzi decoction alleviates the symptoms of functional dyspepsia by regulating brain-gut axis and production of neuropeptides[J]. BMC Complement Altern Med, 2015, 15: 387. PMID: 26508134. PMCID: PMC4623916. DOI: 10.1186/s12906-015-0913-z.
4 He Y, Yang C, Wang P, et al. Child compound Endothelium corneum attenuates gastrointestinal dysmotility through regulating the homeostasis of brain-gut-microbiota axis in functional dyspepsia rats[J]. J Ethnopharmacol, 2019, 240: 111953. PMID: 31082513. DOI: 10.1016/j.jep.2019.111953.
5 Cordner ZA, Li Q, Liu L, et al. Vagal gut-brain signaling mediates amygdaloid plasticity, affect, and pain in a functional dyspepsia model[J]. JCI insight, 2021, 6(6): 144046. PMID: 33591956. PMCID: PMC8026195. DOI: 10.1172/jci.insight.144046.
6 Hyams JS, Di Lorenzo C, Saps M, et al. Functional disorders: children and adolescents[J]. Gastroenterology, 2016, 150(6):1456-1468.e2. PMID: 27144632. DOI: 10.1053/j.gastro.2016.02.015.
7 Kim YS, Lee JS, Lee TH, et al. Plasma levels of acylated ghrelin in patients with functional dyspepsia[J]. World J Gastroenterol, 2012, 18(18):2231-2237. PMID: 22611317. PMCID: PMC3351774. DOI: 10.3748/wjg.v18.i18.2231.
8 Hyams JS, Di Lorenzo C, Saps M, et al. Childhood functional gastrointestinal disorders: child/adolescent[J]. Gastroenterology, 2016, 150(6): 1456-1468.E2. PMID: 27144632. DOI: 10.1053/j.gastro.2016.02.015.
9 Zhu J, Tong H, Ye X, et al. The effects of low-dose and high-dose decoctions of fructus aurantii in a rat model of functional dyspepsia[J]. Med Sci Monit, 2020, 26: e919815. PMID: 32248203. PMCID: PMC7156881. DOI: 10.12659/MSM.919815.
10 徐派的, 张红星, 杨云, 等. 电针对功能性消化不良模型大鼠胃肠动力及VIP和CGRP水平的影响[J]. 中国中西医结合杂志, 2017, 37(3): 360-364. DOI: 10.7661/CJIM.2017.03.0360.
11 M?nnikes H, van der Voort IR, Wollenberg B, et al. Gastric perception thresholds are low and sensory neuropeptide levels high in helicobacter pylori-positive functional dyspepsia[J]. Digestion, 2005, 71(2): 111-123. PMID: 15785037. DOI: 10.1159/000084625.
12 Shindo T, Futagami S, Hiratsuka T, et al. Comparison of gastric emptying and plasma ghrelin levels in patients with functional dyspepsia and non-erosive reflux disease[J]. Digestion, 2009, 79(2): 65-72. PMID: 19246923. DOI: 10.1159/000205740.
13 Lee KJ, Cha DY, Cheon SJ, et al. Plasma ghrelin levels and their relationship with gastric emptying in patients with dysmotility-like functional dyspepsia[J]. Digestion, 2009, 80(1): 58-63. PMID: 19494492. DOI: 10.1159/000215389.
14 Kim YS, Lee JS, Lee TH, et al. Plasma levels of acylated ghrelin in patients with functional dyspepsia[J]. World J Gastroenterol, 2012, 18(18): 2231-2237. PMID: 22611317. PMCID: PMC3351774. DOI: 10.3748/wjg.v18.i18.2231.
15 Tang L, Zeng Y, Li L, et al. Electroacupuncture upregulated ghrelin in rats with functional dyspepsia via AMPK/TSC2/Rheb-mediated mTOR inhibition[J]. Dig Dis Sci, 2020, 65(6): 1689-1699. PMID: 31863340. PMCID: PMC7225202. DOI: 10.1007/s10620-019-05960-5.
16 St-Pierre DH, Martin J, Shimizu H, et al. Association between nesfatin-1 levels and metabolic improvements in severely obese patients who underwent biliopancreatic derivation with duodenal switch[J]. Peptides, 2016, 86: 6-12. PMID: 27681383. DOI: 10.1016/j.peptides.2016.09.014.
17 Zhou XP, Sha J, Huang L, et al. Nesfatin-1/NUCB2 in the amygdala influences visceral sensitivity via glucocorticoid and mineralocorticoid receptors in male maternal separation rats[J]. Neurogastroenterol Motil, 2016, 28(10): 1545-1553. PMID: 27380730. DOI: 10.1111/nmo.12853.
18 Jing FC, Zhang J, Feng C, et al. Potential rat model of anxiety-like gastric hypersensitivity induced by sequential stress[J]. World J Gastroenterol, 2017, 23(42): 7594-7608. PMID: 29204059. PMCID: PMC5698252. DOI: 10.3748/wjg.v23.i42.7594.