Serum mannan-binding lectin levels in preschool children from Shenzhen
CHEN Wei-Dong, XIAO Qin, ZOU De-Xue
Department of Clinical Laboratory, Shenzhen Hospital, Peking University, Shenzhen, Guangdong 518036, China (Email: bayyyz@yahoo.com.cn)
Abstract OBJECTIVE:Mannan-binding lectin (MBL) is a C-type serum lectin that plays a central role in the innate immune response. At present there is no a reference range of serum MBL levels for children in China. This study investigated serum MBL levels in preschool children from Shenzhen. METHODS: A total of 118 children (62 boys and 56 girls) at ages of 3-6 years and sampled randomly from three kindergartens of Shenzhen were enrolled in this study. Serum MBL concentrations were determined using enzyme-linked immunosorbent assay. RESULTS: The mean serum MBL concentration in these children was 779.07±268.98 ng/mL. There were no significant differences in the value of serum MBL between boys and girls (783.89±252.30 ng/mL vs 773.65±288.29 ng/mL) (P>0.05). Sixteen children (13.6%) had MBL concentrations less than 500 ng/mL (the low limited value used abroad), including 14 cases with 50-500 ng/mL and 2 cases with less than 50 ng/mL. CONCLUSIONS: This study provides a reference range of serum MBL concentration for preschool children. MBL may be a useful marker for the prevention of infection in children.
Key words ：
Mannan-binding lectin
Child
preschool
Cite this article:
CHEN Wei-Dong,XIAO Qin,ZOU De-Xue. Serum mannan-binding lectin levels in preschool children from Shenzhen[J]. 中国当代儿科杂志, 2008, 10(2): 149-151.
CHEN Wei-Dong,XIAO Qin,ZOU De-Xue. Serum mannan-binding lectin levels in preschool children from Shenzhen[J]. CJCP, 2008, 10(2): 149-151.
URL:
http://www.zgddek.com/EN/ OR http://www.zgddek.com/EN/Y2008/V10/I2/149
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