Effect of endemic fluorosis on children's intelligence development: a Meta analysis
LIU Ming, QIAN Cong
Department of Health Statistics, China Medical University, Shenyang 110001, China
Abstract OBJECTIVE: To investigate the effect of high levels of fluoride on children's intelligence development by analyzing the literatures systematically. METHODS: The literatures on the relationship between endemic fluorosis and children's intelligence development published between 1995 and 2007 were retrieved electronically and manually. A total of 13 relevant literatures that met the inclusion criteria were included for Meta analysis. Meta analysis was performed using the Coorporative network software RevMan 4.3. RESULTS: The subjects of the 13 literatures included 2 508 children from the high fluoride group and 2 330 children from the control group. Meta analysis showed these literatures were inhomogenous (χ2=268.05, P<0.01). Therefore a random effect model was used. The average effect scale (OR=-7.14; 95%CI: -9.90, -4.37) suggested a negative correlation between high fluorosis exposure and children's intelligence development. CONCLUSIONS: Exposure to high levels of fluoride may adversely influence children's intelligence development.
Key words :
Endemic fluorosis
Intelligence development
Meta analysis
Child
Cite this article:
LIU Ming,QIAN Cong. Effect of endemic fluorosis on children's intelligence development: a Meta analysis[J]. 中国当代儿科杂志, 2008, 10(6): 723-725.
LIU Ming,QIAN Cong. Effect of endemic fluorosis on children's intelligence development: a Meta analysis[J]. CJCP, 2008, 10(6): 723-725.
URL:
http://www.zgddek.com/EN/ OR http://www.zgddek.com/EN/Y2008/V10/I6/723
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