Serologic examination for childhood herpes simplex virus infection
TANG Jian-Ping, YANG Yu-Jia, ZHANG Dan, LI Li-Ping
Department of Pediatrics, Xiangya Hospital, Central South University, Changsha 410008, China.jpingtang@126.com
Abstract OBJECTIVE: This study was designed to investigate the value of serologic examination in the diagnosis of childhood herpes simplexvirus (HSV) infection. METHODS: Serum samples were collected from 2 436 outpatients and inpatients. The samples were divided into two groups. Group 1 consisted of 321 samples which were assayed for HSV-1 IgG, HSV-1 IgM, HSV-2 IgG or HSV-2 IgM antibody using herpes simplex virus antibody kits between January 2003 and November 2005. Group 2 consisted of 2 115 samples which were assayed for HSV-2 IgG and IgM antibodies by TORCH testing between October 2004 and November 2005. RESULTS: In Group 1, the total seroprevalence of HSV infection was 44.6%, with 38.9% being HSV-1 positive and 15.9% HSV-2 positive; HSV-IgM positivity was found in 41.1% and 25.5% were HSV-IgG positive; HSV-1 seroprevalence significantly increased with age (P <0.05). In Group 2 the seroprevalence of HSV-2 infection was 1.9%; all of the samples were HSV-2 IgG positive. CONCLUSIONS: HSV serologic examination is useful in the diagnosis of HSV infection in children.
Key words ：
Herpes simplex virus
Serologic examination
Child
Cite this article:
TANG Jian-Ping,YANG Yu-Jia,ZHANG Dan et al. Serologic examination for childhood herpes simplex virus infection[J]. 中国当代儿科杂志, 2006, 8(6): 476-478.
TANG Jian-Ping,YANG Yu-Jia,ZHANG Dan et al. Serologic examination for childhood herpes simplex virus infection[J]. CJCP, 2006, 8(6): 476-478.
URL:
http://www.zgddek.com/EN/ OR http://www.zgddek.com/EN/Y2006/V8/I6/476
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