Relationship between anorexia and gastric motility in children
DONG Mei-Ling, BAO Yun-Fang
Department of Pediatrics, Shibei Hospital of Shanghai, Shanghai 200435, China. Email:dongml888@126.com
Abstract OBJECTIVE: This study examined the changes of the gastric motility and the therapeutic effect of domperidone in children with anorexia. METHODS: Forty-five children with anorexia were given a 3 week-course of oral domperidone, with a dosage of 0.3 mg/kg, three times daily. Before and after treatment the gastric emptying test was performed through the real-time ultrasonography in 42 out of the 45 patients. Thirty healthy children served as controls. RESULTS: There were significant differences in the gastric emptying half-time (GET 1/2), and the frequency and amplitude of antral contractions between the children with anorexia and healthy controls. After domperidone treatment, the GET 1/2 was shortened and the frequency and amplitude of antral contractions were significantly increased in children with anorexia. Their clinical symptoms improved markedly. CONCLUSIONS: The abnormalities of gastric motility might be associated with the development of anorexia. Domperidone was found to be effective in the treatment of childhood anorexia.
Key words ：
Anorexia
Gastric motility
Gastric emptying
Domperidone
Child
Cite this article:
DONG Mei-Ling,BAO Yun-Fang. Relationship between anorexia and gastric motility in children[J]. 中国当代儿科杂志, 2005, 7(4): 331-332.
DONG Mei-Ling,BAO Yun-Fang. Relationship between anorexia and gastric motility in children[J]. CJCP, 2005, 7(4): 331-332.
URL:
http://www.zgddek.com/EN/ OR http://www.zgddek.com/EN/Y2005/V7/I4/331
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