Childhood Castleman's Disease
LIANG Shao-Jun, MEI Zhi-Yong, LI Wen-Yi, ZHANG Yu-Lan
Department of Pediatrics, Second Affiliated Hospital of Zhongshan University, Guangzhou 510120, China
Abstract Castleman's disease (CD) is a localized or systemic angiofollicular lymphoproliferative disorder of unknown etiology and pathogenesis and rarely seen in children. The disorder manifest lymph node hyperplasia with or without systemic symptoms and can be classified to unicentric CD (UCD) and muticentric CD (MCD). The histological features include three types: hyaline vascular, plasma cell and mixed variant. The diagnosis of CD was comfirmed by lymph node biopsy. No effective treatment for patients with MCD has been found so far and some of which may be respondent to corticosteroid and interferon α. The patients with UCD can be improved by surgical intervention with/or radiotherapy.
Key words ：
Castleman's disease
Manifestation
Pathology
Treatment
Child
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