OBJECTIVE: To compare the therapeutic effect and complications of high frequency oscillatory ventilation (HFOV) and conventional mechanical ventilation (CMV) in neonates with the respiratory distress syndrome (RDS). METHODS: Meta analysis was used to evaluate the data extracted from 12 published papers. Combined Odds ratio (OR) and its 95% confidence interval were calculated. RESULTS: Compared to CMV, HFOV was found to improve pulmonary function ( P <0.05) and reduce the incidence of chronic lung disease (CLD) ( P <0.01). However, the use of HFOV resulted in an increase in intracranial hemorrhage (ICH) ( P <0.05) in infants with RDS. There was no difference in the incidence of air leak induced by HFOV and CMV. CONCLUSIONS: HFOV is more beneficial than CMV in its therapeutic effect on neonatal RDS and in its ability to reduce the incidence of CLD. This benefit may be offset by the increase in the occurrence of ICH when using this modality."/>
Meta analysis of prospective clinical trials: high frequency oscillatory ventilation in the treatment of the neonatal respiratory distress ayndrome
Abstract OBJECTIVE: To compare the therapeutic effect and complications of high frequency oscillatory ventilation (HFOV) and conventional mechanical ventilation (CMV) in neonates with the respiratory distress syndrome (RDS). METHODS: Meta analysis was used to evaluate the data extracted from 12 published papers. Combined Odds ratio (OR) and its 95% confidence interval were calculated. RESULTS: Compared to CMV, HFOV was found to improve pulmonary function ( P <0.05) and reduce the incidence of chronic lung disease (CLD) ( P <0.01). However, the use of HFOV resulted in an increase in intracranial hemorrhage (ICH) ( P <0.05) in infants with RDS. There was no difference in the incidence of air leak induced by HFOV and CMV. CONCLUSIONS: HFOV is more beneficial than CMV in its therapeutic effect on neonatal RDS and in its ability to reduce the incidence of CLD. This benefit may be offset by the increase in the occurrence of ICH when using this modality.
ZHANG Jin-Ping,XIAO Xin,ZHOU Xiao-Guang. Meta analysis of prospective clinical trials: high frequency oscillatory ventilation in the treatment of the neonatal respiratory distress ayndrome[J]. 中国当代儿科杂志, 2003, 5(2): 104-108.
ZHANG Jin-Ping,XIAO Xin,ZHOU Xiao-Guang. Meta analysis of prospective clinical trials: high frequency oscillatory ventilation in the treatment of the neonatal respiratory distress ayndrome[J]. CJCP, 2003, 5(2): 104-108.
