OBJECTIVE: To study the relationship between α-smooth muscle actin(α-SMA) and clinical symptoms(hypertension and hyperlipoproteinemia ) in children with mesangial proliferative glomerulonephritis(MsPGN). METHODS: Expression of α-SMA was detected using immunohistochemistry and computer image evaluation in 33 children with MsPGN. RESULTS: The expression of α-SMA was higher in MsPGN children with hypertension and/or hyperlipoproteinemia than that in MsPGN children without hypertension and/or hyperlipoproteinemia(P < 0.05). CONCLUSIONS: Expression of α-SMA by mesangial cells appears to be activated by hypertension and hyperlipoproteinemia in children with MsPGN.

"/> Relationship between the Expression of α-mooth Muscle Actin and Clinical ymptoms in Children with Mesangial Proliferative Glomerulonephritis
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中国当代儿科杂志  2002, Vol. 4 Issue (2): 106-108    DOI:
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Relationship between the Expression of α-mooth Muscle Actin and Clinical ymptoms in Children with Mesangial Proliferative Glomerulonephritis
HU Ling
Department of Pediatrics,hird Affiliated ospital of Nanjing Medical University, Yizheng,Jiangsu 211900, China
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