OBJECTIVE: To study the roles of nitric oxide (NO) and oxygen free radical (OFR) in the pathogenesis in children with asthma or Mycoplasma (MP) pneumonia. METHODS: The levels of NO, lipid peroxidation (LPO), thromboxane B 2 (TXB 2) and circulating endothelial cells (CEC) were detected in 36 children with asthma (asthma group), 40 MP pneumonia children (MP group) and 15 normal children (control group). RESULTS: The levels of NO, LPO, TXB 2 and CEC in the acute period in the asthma group [( 162.27 ± 36.12 ) μmol/L,( 8.62 ±0.87 ) nmol/ml,( 229.11 ± 64.75 ) pg/ml and ( 6.13 ± 1.15 ) n/ 0.9 μl , respectively] and in the MP group [( 95.52 ± 33.84 ) μmol/L,( 5.76 ± 0.53 ) nmol/ml,( 388.72 ± 80.09 ) pg/ml and ( 6.36 ± 1.02 ) n/ 0.9 μl , respectively] were significantly higher than those in the control group [( 68.57 ± 13.80 ) μmol/L,( 4.62 ± 1.80 ) nmol/ml,( 105.76 ± 20.10 ) pg/ml and ( 4.40 ± 1.04 ) n/ 0.9 μl , respectively](P< 0.01 ). The levels of NO and LPO in the asthma group were much higher thanthose in the MP group (P< 0.01 ), while the TXB 2 level was higher in the MP group than that in the asthma group(P< 0.01 ). The above 4 index levels decreased both in the asthma and MP groups in the recovery period. Of them, the TXB 2 and LPO levels were lowered to normal, while the NO and CEC levels remained higher ( 82.64 ± 20.56 ) μmol/L and ( 5.41 ± 1.29 ) nmol/L in the asthma group; ( 86.12 ± 21.34 ) μmol/L and ( 5.57 ± 1.12 ) n/ 0.9 μl in the MP group] than those in the control group two weeks later (P< 0.05 or 0.01 ). than those in the control group two weeks later (P< 0.05 or 0.01 ). CONCLUSIONS: Both NO and OFR take part in the pathogenesis of asthma and MP pneumonia. NO and LPO appear to be the sensitive indices for asthma and TXB 2 for MP pneumonia. NO could show the extent of tissue repair after injuries."/>
Changes and Significance of Serum Nitric Oxide and Oxygen Free Radical in Children with Asthma or Mycoplasma Pneumonia
Abstract OBJECTIVE: To study the roles of nitric oxide (NO) and oxygen free radical (OFR) in the pathogenesis in children with asthma or Mycoplasma (MP) pneumonia. METHODS: The levels of NO, lipid peroxidation (LPO), thromboxane B 2 (TXB 2) and circulating endothelial cells (CEC) were detected in 36 children with asthma (asthma group), 40 MP pneumonia children (MP group) and 15 normal children (control group). RESULTS: The levels of NO, LPO, TXB 2 and CEC in the acute period in the asthma group [( 162.27 ± 36.12 ) μmol/L,( 8.62 ±0.87 ) nmol/ml,( 229.11 ± 64.75 ) pg/ml and ( 6.13 ± 1.15 ) n/ 0.9 μl , respectively] and in the MP group [( 95.52 ± 33.84 ) μmol/L,( 5.76 ± 0.53 ) nmol/ml,( 388.72 ± 80.09 ) pg/ml and ( 6.36 ± 1.02 ) n/ 0.9 μl , respectively] were significantly higher than those in the control group [( 68.57 ± 13.80 ) μmol/L,( 4.62 ± 1.80 ) nmol/ml,( 105.76 ± 20.10 ) pg/ml and ( 4.40 ± 1.04 ) n/ 0.9 μl , respectively](P< 0.01 ). The levels of NO and LPO in the asthma group were much higher thanthose in the MP group (P< 0.01 ), while the TXB 2 level was higher in the MP group than that in the asthma group(P< 0.01 ). The above 4 index levels decreased both in the asthma and MP groups in the recovery period. Of them, the TXB 2 and LPO levels were lowered to normal, while the NO and CEC levels remained higher ( 82.64 ± 20.56 ) μmol/L and ( 5.41 ± 1.29 ) nmol/L in the asthma group; ( 86.12 ± 21.34 ) μmol/L and ( 5.57 ± 1.12 ) n/ 0.9 μl in the MP group] than those in the control group two weeks later (P< 0.05 or 0.01 ). than those in the control group two weeks later (P< 0.05 or 0.01 ). CONCLUSIONS: Both NO and OFR take part in the pathogenesis of asthma and MP pneumonia. NO and LPO appear to be the sensitive indices for asthma and TXB 2 for MP pneumonia. NO could show the extent of tissue repair after injuries.
KONG Ling-Fen,LI Zhao-Hui,GUO Lu-Hong. Changes and Significance of Serum Nitric Oxide and Oxygen Free Radical in Children with Asthma or Mycoplasma Pneumonia[J]. 中国当代儿科杂志, 2002, 4(1): 25-27.
KONG Ling-Fen,LI Zhao-Hui,GUO Lu-Hong. Changes and Significance of Serum Nitric Oxide and Oxygen Free Radical in Children with Asthma or Mycoplasma Pneumonia[J]. CJCP, 2002, 4(1): 25-27.
