Effect of Glucocorticoid on Serum Cytokines in Children with the Nephrotic Syndrome
YU Li, ZHUO Mei-Ying, YANG Xiao-Su, WENG Zhi-Yuan, ZHONG Zhi-Min, ZHANG You-Xiang
Department of Pediatrics, First People’s Hospital of Guangzhou, Guangzhou 510180, China
Abstract OBJECTIVE: To explore the effect of glucocorticoid on serum IL-1, IL-6, IL-8 and TNFα in children with the nephrotic syndrome (NS). METHODS: IL-1, IL-6, IL-8 and TNFα in serum were detected using ELISA in 24 children with NS before and after the treatment with glucocorticoids. RESULTS: Significant differences of IL-1 ［(195±25) ng/L vs (120±25) ng/L］, IL-6 ［(355±62) ng/L vs (200±23) ng/L］, IL-8 ［(286±55) ng/L vs (178±32) ng/L］ and TNFα ［(265±36) ng/L vs (110±40) ng/L］ were found between the two groups before and after the treatment (P<0.01). CONCLUSIONS: It is suggested that glucocorticoids might inhibit serum IL-1, IL-6, IL-8 and TNFα in children with NS.
Key words ：
Glucocorticoid
Cytokine
Nephrotic syndrome
Child
Cite this article:
YU Li,ZHUO Mei-Ying,YANG Xiao-Su et al. Effect of Glucocorticoid on Serum Cytokines in Children with the Nephrotic Syndrome[J]. 中国当代儿科杂志, 2001, 3(5): 509-511.
YU Li,ZHUO Mei-Ying,YANG Xiao-Su et al. Effect of Glucocorticoid on Serum Cytokines in Children with the Nephrotic Syndrome[J]. CJCP, 2001, 3(5): 509-511.
URL:
http://www.zgddek.com/EN/ OR http://www.zgddek.com/EN/Y2001/V3/I5/509
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