Economic evaluation on diagnosis of congenital cytomegalovirus infection by fluorescent quantitative polymerase chain reaction in neonates

LI Lu-Quan, YU Jia-Lin, TAN Jun-Jie

Chinese Journal of Contemporary Pediatrics ›› 2010, Vol. 12 ›› Issue (10) : 796-798.

PDF(932 KB)
PDF(932 KB)
Chinese Journal of Contemporary Pediatrics ›› 2010, Vol. 12 ›› Issue (10) : 796-798.
CLINICAL RESEARCH

Economic evaluation on diagnosis of congenital cytomegalovirus infection by fluorescent quantitative polymerase chain reaction in neonates

  • LI Lu-Quan, YU Jia-Lin, TAN Jun-Jie
Author information +
History +

Abstract

OBJECTIVE: To explore the cost-effectiveness of the diagnosis of congenital cytomegalovirus (CMV) infection by fluorescent quantitative polymerase chain reaction (FQ-PCR) in neonates. METHODS: Serum CMV immunoglobulin M (CMV-IgM) and CMV-IgG were detected using ELISA in 610 neonates aged less than 14 days. CMV DNA content was detected by FQ-PCR. The cost-effectiveness analysis was then performed. RESULTS: The positive rate of FQ-PCR in neonates with positive CMV-IgM was 42.9% (15/35), while, 2.9% (16/547) in neonates with positive CMV-IgG. The mean logarithm values of CMV DNA in neonates with positive CMV-IgM were higher than those in neonates with positive CMV-IgG (5.79±1.24 vs 4.11±0.87; P<0.01). The costs of the diagnosis of CMV infection by FQ-PCR were 256 RMB/case in neonates with positive CMV-IgM, and 3 760 RMB/case in neonates with positive CMV-IgG. CONCLUSIONS: The CMV DNA content in neonates with positive CMV-IgM is higher than that in neonates with positive CMV-IgG. Diagnosis of congenital CMV infection by FQ-PCR in neonates with positive CMV-IgG is not suitable for large scale epidemiological survey because of high cost-effectiveness ratio.[Chin J Contemp Pediatr, 2010, 12 (10):796-798]

Key words

Cytomegalovirus / Congenital infection / Fluorescent quantitative polymerase chain reaction / Neonate

Cite this article

Download Citations
LI Lu-Quan, YU Jia-Lin, TAN Jun-Jie. Economic evaluation on diagnosis of congenital cytomegalovirus infection by fluorescent quantitative polymerase chain reaction in neonates[J]. Chinese Journal of Contemporary Pediatrics. 2010, 12(10): 796-798

References

[1]Leung AK, Sauve RS, Davies HD. Congenital cytomegalovirus infection[J]. J Natl Med Assoc, 2003, 95(3):213-218.
[2]马艳萍,齐莹,吉耀华,刘庆,王继东,孙峥嵘,等. 荧光定量聚合酶链式反应法检测婴儿尿液人巨细胞病毒对人巨细胞病毒感染的诊断意义[J].实用儿科临床杂志,2007,22(22):1696-1712.
[3]中华医学会儿科分会感染消化学组.巨细胞病毒感染诊断方案[J].中华儿科杂志,1999,37(7):441.
[4]袁中群,杜风泽,李玲霜.育龄妇女巨细胞病毒感染优生管理措施的研究[J].中国优生与遗传杂志,2004,12(3):115-116.

PDF(932 KB)

Accesses

Citation

Detail

Sections
Recommended

/