Abstract OBJECTIVE: To study the value of serum Cystatin C (Cyst C) in the evaluation of glomerular filtration function in children with viral encephalitis. METHODS: Serum levels of Cyst C, urea nitrogen (BUN) and creatinine (Cr) were measured in 92 children with viral encephalitis and in 50 healthy children as a control group. According to glomerular filtration rate (GFR), the encephalitis group was subdivided into normal renal function, renal insufficiency in the compensatory or decompensatory stage, and renal failure /end-stage groups. RESULTS: Serum levels of Cyst C, BUN and Cr in the encephalitis group increased and GFR decreased significantly compared with those in the control group (P<0.01). With the decline of renal function, GFR decreased and serum levels of Cyst C, BUN and Cr increased gradually. Serum levels of Cyst C and GFR were significantly different among the encephaitis subgroups (P<0.01). For serum levels of BUN and Cr, there were significant differences among the subgroups except between the normal renal function and the compensatory renal insufficiency groups. Serum Cyst C level was positively correlated with serum BUN and Cr levels, and negatively correlated with GFR. CONCLUSIONS: The children with viral encephalitis have different degrees of renal impairments. Cyst C appears to be superior to BUN and Cr as a marker for the evaluation of glomerular filtration function. Measurement of serum Cyst C levels is very valuable in renal function monitoring in children with viral encephalitis.
RUAN Yi-Yan,FENG Jun-Tan,HUANG Zhang-Qiong et al. Diagnostic value of serum Cystatin C in renal function impairments in children with viral encephalitis[J]. 中国当代儿科杂志, 2011, 13(2): 119-122.
RUAN Yi-Yan,FENG Jun-Tan,HUANG Zhang-Qiong et al. Diagnostic value of serum Cystatin C in renal function impairments in children with viral encephalitis[J]. CJCP, 2011, 13(2): 119-122.
[1]Uzun H, Ozmen Keles M, Ataman R, Aydin S, Kalender B, Uslu E, et al. Serum cystatin C level as a potentionally good marker for impaired kidney function[J]. Clin Biochem, 2005, 38(9): 792-798.
[2]Bicik Z, Bahcebasi T, Knlaksizoglu S, Yavuz O. The efficiency of cystatin C assay in the prediction of glomerular filtration rate: is it a more reliable marker for renal failure?[J]. Clin Chem Lab Med, 2005, 43(8): 855-861.
[4]Grubb A, Nyman U, Bjork J, Lindstrom V, Rippe B, Sterner G, et al. Simple cystatin C-based prediction equations for glomerular filtration rate compared with the modification of diet in renal disease prediction equation for adults and the Schwartz and the Counahan-Barratt prediction equations for children[J]. Clin Chem, 2005, 51(8):1420-1431.
[5]Hogg RJ, Furth S, Lemley KV, Portman R, Schwartz GJ, Coresh J, et al. National kidney foundation's kidney disease outcomes quality initiative clinical practice guidelines for chronic kidney disease in children and adolescents: evaluation, classification, and stratification[J]. Pediatrics, 2003, 111(6 Pt 1): 14161421.
[6]Newman DJ. Cystatin C[J]. Ann Clin Biochem, 2002, 39(Pt2): 89-104.
[7]Filler G, Bokenkamp A, Hofmann W, Le Bricon T, Martinez-Bru C, Grubb A. Cystatin C as a mark of GFR-history, indications, and future research[J]. Clin Biochem, 2005, 38(1): 1-8.
[8]Chew JS, Saleem M, Florkowski CM, George PM. Cystatin C-A paradigm of evidence based laboratory medicine[J]. Clin Biochem Rev, 2008, 29(2): 47-62.
[9]Mussap M, Plebani M. Biochemistry and clinical role of human csytatin C[J]. Crit Rev Clin Lab Sci, 2004, 41(5-6): 467-550.
[10]Bagshaw SM, Gibney RT. Conventional markars of kidney function[J]. Crit Care Med, 2008, 36(4 Suppl): S152-S158.