Abstract OBJECTIVE: To study the levels of CD4+CD25+CD127- and CD3+CD4-CD8- regulatory T (Treg) cells in peripheral blood of children with idiopathic thrombocytopenic purpura (ITP). METHODS: The flow cytometry was used to detect the expression of CD4+CD25+CD127- and CD3+CD4-CD8- Treg cells in peripheral blood of 33 children with ITP and 21 healthy children. RESULTS: The expression levels of CD4+CD25+CD127-[(2.7±1.7)% vs (4.8±1.6)%; P<0.01] and CD3+CD4-CD8-[(5.2±3.1)% vs (8.1±3.5)%; P<0.01]Treg cells in children with ITP were significantly lower than in the controls. CONCLUSIONS: The expression levels of CD4+CD25+CD127- and CD3+CD4-CD8- Treg cells decrease in children with ITP, suggesting that CD4+CD25+CD127- and CD3+CD4-CD8- Treg cells might play a role in the pathogenesis of ITP.
WANG Xue-Ping,QIU Yun-Shu,HAO Guo-Ping et al. Levels of regulatory T cells in peripheral blood of children with idiopathic thrombocytopenic purpura[J]. 中国当代儿科杂志, 2011, 13(4): 282-284.
WANG Xue-Ping,QIU Yun-Shu,HAO Guo-Ping et al. Levels of regulatory T cells in peripheral blood of children with idiopathic thrombocytopenic purpura[J]. CJCP, 2011, 13(4): 282-284.
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