Abstract OBJECTIVE: To study the changes and clinical significance of serum levels of 25-(OH)D3 and total IgE in children with asthma. METHODS: Thirty children with asthma, 40 children with asthmatic bronchitis, and 40 healthy children were enrolled. Double-antibody radioimmunoassay was used to detect the levels of serum 25-(OH)D3 and total IgE. RESULTS: Serum 25-(OH)D3 levels (18±3 ng/Ml)decreased significantly in the asthmatic group compared with those in the asthmatic bronchitis group (43±3 ng/mL) and the control group (43±3 ng/mL) (P＜0.01). In contrast, serum total IgE levels (192±16 IU/mL) increased significantly in the asthmatic group compared with those in the asthmatic bronchitis group (123±14 IU/mL) and the control group (118±15 IU/mL) (P<0.01). Serum 25-(OH)D3 levels were negatively correlated with serum total IgE levels in asthmatic children (r=-0.783, P<0.01). There were no correlation between serum 25-(OH)D3 levels and serum total IgE level in the asthmatic bronchitis and the control groups. CONCLUSIONS: 25-(OH)D3 may play an important role in the pathogenesis of asthma. The increased serum 25-(OH)D3 level may inhibit total IgE expression, suggesting that increasing serum 25-(OH)D3 level might be a new option for the prevention and treatment of asthma.
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