急性淋巴细胞白血病患儿MTHFR基因多态性与大剂量甲氨蝶呤毒副反应的关系

doi:10.7499/j.issn.1008-8830.2013.03.009

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Abstract OBJECTIVE: To study the association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and toxicities after high-dose methotrexate (HD-MTX) infusion in children with acute lymphocytic leukemia (ALL). METHODS: MTHFR variants in 52 children with ALL were determined by reverse transcriptase-polymerase chain reaction-denaturing gradient gel electrophoresis and sequencing. Toxicities of children who received HD-MTX chemotherapy were evaluated according to the National Cancer Institute-Common Toxicity Criteria (NCI-CTC). RESULTS: The children carrying MTHFR 1298AC had a higher risk of developing thrombocytopenia compared with the carriers of the 1298 AA genotype (OR=13.7, 95%CI=1.18-159.36, P=0.036). There was no significant difference in HD-MTX chemotherapy-related adverse effects between the patients with different MTHFR C677T or G1793A genotypes. CONCLUSIONS: MTHFR A1298C polymorohism may associate with the toxicity of HD-MTX chemotherapy in children with ALL.

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	Articles by authors
	ZHENG Miao-Miao
	YUE Li-Jie
	CHEN Xiao-Wen
	WEN Fei-Qiu
	LI Chang-Gang
	YANG Chun-Lan
	XIE Cai
	DING Hui

Key words： Methylenetetrahydrofolate reductase Single nucleotide polymorphism Acute lymphoblastic leukemia Methotrexate Adverse reaction Child

Cite this article:

ZHENG Miao-Miao,YUE Li-Jie,CHEN Xiao-Wen et al. Relationship between the methylenetetrahydrofolate reductase gene polymorphism and adverse reactions of high-dose methotrexate in children with acute lymphocytic leukemia[J]. CJCP, 2013, 15(3): 201-206.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2013.03.009 OR http://www.zgddek.com/EN/Y2013/V15/I3/201

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