Abstract OBJECTIVE: To summarize the spectrum of disease and common diseases that cause death in children admitted to the Pediatric Intensive Care Unit (PICU), Shengjing Hospital of China Medical University between 2005 and 2012. METHODS: A retrospective analysis was carried out on the clinical data of 4484 children admitted to the PICU of Shengjing Hospital bettween 2005 and 2012. RESULTS: Acute bronchopneumonia, which was found in 1099 (24.51%) of the 4484 cases, was the most common disease in the PICU bettween 2005 and 2012. The incidence of intracranial infection, sepsis, hand-foot-mouth disease and trauma showed an increasing trend from 2005 to 2012, but that of non-traumatic intracranial hemorrhage, epilepsy and congenital heart disease showed a decreasing trend. The mortality decreased from 11.5% in 2005 to 3.1% in 2012, and the overall mortality was significantly higher in 2005-2008 than in 2009-2012 (11.98% vs 4.41%; P<0.01). The main causes of death included severe acute bronchial pneumonia, severe sepsis, complex congenital heart disease, severe cerebral trauma, respiratory failure, severe hand-foot-mouth disease, acute poisoning and circulatory failure. CONCLUSIONS: Acute bronchopneumonia was the most common disease in the PICU of Shengjing Hospital bettween 2005 and 2012, but the spectrum of disease changed over time. The mortality showed a decreasing trend among the children in the PICU bettween 2005 and 2012, and the main causes of death included severe acute bronchial pneumonia and severe sepsis.
LI Jiu-Jun,CHEN Yan-Fei,LIN Ye-Xin. Investigation of disease spectrum in the PICU of Shengjing Hospital of China Medical University between 2005 and 2012[J]. CJCP, 2013, 15(6): 472-476.
LI Jiu-Jun,CHEN Yan-Fei,LIN Ye-Xin. Investigation of disease spectrum in the PICU of Shengjing Hospital of China Medical University between 2005 and 2012[J]. CJCP, 2013, 15(6): 472-476.
［1］Elliott SR, Beeson JG. Estimating the burden of global mortality in children aged <5 years by pathogen-specific causes［J］. Clin Infect Dis, 2008, 46(11):1794-1795.
［2］World Health Organization (WHO).World Health Statistics［EB/OB］.［2013-03-10］. http://www.who.int.
［3］Ladhani S, Konana OS, Mwarumba S, English MC. Bacteraemia due to Staphylococcus aureus［J］. Arch Dis Child, 2004, 89(6):568-571.
［4］Lautenschlager S, Herzog C, Zimmerli W. Course and outcome of bacteremia due to Staphylococcus aureus: evaluation of different clinical case definitions［J］.Clin Infect Dis, 1993, 16(4):567-573.
［5］Carrol ED, Thomson AP, Hart CA. Procalcitonin as a marker of sepsis［J］. Int J Antimicrob Agents, 2002, 20(1):1-9.
