Abstract Objective To investigate and summarize the clinical features and comorbidities of Asperger syndrome (AS) in children and to provide a theoretical basis for improving the understanding and diagnosis of AS. Methods Inquiry of medical history, physical examination, behavioral observation, psychiatric examination, questionnaire survey, and the Wechsler Intelligence Scale were used to summarize and analyse the clinical data of 95 children with AS, including chief complaint, symptoms, perinatal and familial conditions, family genetic history, and common comorbidities. Results AS was more common in male children, with hyperactivity, inattention, and social withdrawal as frequent chief complaints. The main clinical manifestations included poor communication skills (95%), restricted interest (82%), repetitive and stereotyped patterns of behavior (77%), semantic comprehension deficit (74%), and indiscipline (68%). Verbal IQ was higher than performance IQ in most patients. The comorbidities of AS included attention deficit hyperactivity disorder (ADHD) (39%), emotional disorder (18%), and schizophrenia (2%); emotional disorder was more common in patients aged 13-16 years, while ADHD was more common in patients aged 7-16 years. Among these patients, 61% had fathers with introverted personality, 43% had mothers with introverted personality, and 19% had a family history of mental illness. Conclusions AS has specific clinical manifestations. It is essential to know more about the clinical features and comorbidities of AS, which is helpful for early identification and diagnosis of AS.
American Psychiatric Association. Diagnostic and statistical manual of Mental Disorders[M]. 4th ed. Washington DC: American Psychiatric Association, 1994: 75-77.
[2]
American Psychiatric Association. Diagnostic and statistical manual of Mental Disorders[M]. 4th ed. Washington DC: American Psychiatric Association, 1994: 80-85.
Sverd J. Psychiatric disorders in individuals with pervasive developmental disorder[J]. J Psychiatr Pract, 2003, 9(2): 111-127.
[8]
Gillberg C, Billstedt E. Autism and Asperger syndrome: coexistence with other clinical disorders[J]. Acta Psychiatric Scand, 2000, 102(5): 321-330.
[9]
Rosenberg RE, Kaufmann WE, Law JK, Law PA. Parent report of community psychiatric comorbid diagnoses in autism sepectrum disorders[J]. Autism Res Treat, 2011, 2011: 405849.
[10]
Magnuson KM, Constantino JN. Characterization of depression in children with autism spectrum disorders[J]. J Dev Behav Pediatr, 2011.[Epub ahead of print]
[11]
Ghanizadah A. Comorbidity and factor analysis on attention deficit hyperactivity disorder and autism spectrum disorder DSM-IV-derived items[J]. J Res Med Sci, 2012, 17(4): 368-372.
