Abstract Objective To investigate the survival rate, complications during hospitalization, and prognostic factors in extremely preterm infants (gestational age less than 28 weeks) in the neonatal intensive care unit (NICU). Methods A retrospective analysis was performed on 90 extremely preterm infants who were admitted to the NICU between January 2011 and March 2013 to investigate the perinatal data, delivery and resuscitation, ventilation/ oxygen supply during hospitalization, mortality, and the incidence of severe (grade III/IV) intraventricular hemorrhage (IVH), bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP), patent ductus arteriosus (PDA), and septicemia. Results Among the 90 extremely preterm infants, the gestational age, birth weight, overall survival rate, mortality, and withdrawal rate were 26±1 weeks, 898±165 g, 57%, 9%, and 34%, respectively. The incidence rates of neonatal respiratory distress syndrome, BPD, PDA, ROP, and grade III/IV IVH were 88%, 85%, 69%, 68%, and 31%, respectively. The surviving infants had a mean length of hospital stay of 83±18 days and a mean weight at discharge of 2419±300 g. The multivariate logistic regression analysis showed that grade III/IV IVH and pulmonary hemorrhage were high-risk factors for death or withdrawal, while antenatal corticosteroids were the protective factor for outcome (PConclusions The survival rate of extremely preterm infants is still much lower than that in developed countries. grade III/IV IVH, and pulmonary hemorrhage are important prognostic factors.
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Cite this article:
CUI Yin-Zhu,ZHANG Qian-Shen,HE Hong-Yun et al. Analysis of survival and prognostic factors in extremely preterm infants[J]. CJCP, 2014, 16(6): 596-600.
CUI Yin-Zhu,ZHANG Qian-Shen,HE Hong-Yun et al. Analysis of survival and prognostic factors in extremely preterm infants[J]. CJCP, 2014, 16(6): 596-600.
The Canadian Neonatal Network Annual Report 2009 Rapport Annuel[R]. 2009.
[4]
Barbara J, Stoll BJ, Hansen NI, et al. Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network[J].Pediatrics, 2010 126(3): 443-456.
Kugelman A, Bader D, Lerner-Geva L, et al. Poor outcomes at discharge among extremely premature infants: a national population-based study[J].Arch Pediatr Adolesc Med, 2012, 166(6): 543-550.
[7]
Mori R K S F M. Neonatal Research Network Japan. Antenatal Corticosteroids Promote Survival of Extremely Preterm Infants Born at 22 to 23 Weeks of Gestation[Z]. 2011.159, 110-114.
[8]
Miracle X, Di Renzo GC, Stark A, et al. Guideline for the use of antenatal corticosteroids for fetal maturation[J].J Perinat Med, 2008, 36(3): 191-196.
[9]
Tagare A, Chaudhari S, Kadam S, et al. Mortality and morbidity in extremely low birth weight (ELBW) infants in a neonatal intensive care unit[J].Indian J Pediatr, 2013, 80(1): 16-20.
Austeng D, Kallen K B, Ewald U W, et al. Incidence of retinopathy of prematurity in infants born before 27 weeks' gestation in Sweden[J].Arch Ophthalmol, 2009, 127(10): 1315-1319.
