Clinical significance of anti-neutrophil cytoplasmic antibodies and anti-endothelial cell antibodies in children with Kawasaki disease

ZHAO Jian-Mei; WANG Xiao-Hua

doi:10.7499/j.issn.1008-8830.2014.07.017

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Chinese Journal of Contemporary Pediatrics ›› 2014, Vol. 16 ›› Issue (7) : 740-744. DOI: 10.7499/j.issn.1008-8830.2014.07.017

CLINICAL RESEARCH

Clinical significance of anti-neutrophil cytoplasmic antibodies and anti-endothelial cell antibodies in children with Kawasaki disease

ZHAO Jian-Mei, WANG Xiao-Hua

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Abstract

Objective To study the clinical significance of anti-endothelial cell antibodies (AECA) and antineutrophil cytoplasmic antibodies (ANCA) in Kawasaki disease (KD) and its complication of coronary arterial lesions (CAL). Methods Forty-two children with KD, as well as 20 children with fever caused by respiratory infection (fever control group) and 15 children for selective operation (normal control group), were included in the study. Serum levels of AECA and ANCA were measured using enzyme-linked immunosorbent assay. Echocardiography was performed to evaluate CAL in KD patients. Results During the acute phase, the KD patients had significantly higher serum AECA and ANCA levels than the two control groups (P<0.01). The KD patients had reduced serum ANCA levels (P<0.01) in the remission phase, but they were still higher than those of the two control groups (P<0.05). Among KD patients, those with CAL had significantly higher ANCA levels than those without CAL (P<0.01) in the acute phase. There was a positive correlation between serum ANCA levels and the ratio of left coronary artery to aortic annular diameter in KD patients with CAL (r=0.88, P<0.01). Conclusions AECA and ANCA may be involved in vasculitis and CAL among children with KD. Serum levels of AECA and ANCA may be used as indicators for the diagnosis of suspected KD cases in the acute phase. Elevated ANCA level has a certain predictive value for CAL.

Key words

Kawasaki disease / Anti-endothelial cell antibody / Anti-neutrophil cytoplasmic antibody / Coronary artery lesion / Child

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ZHAO Jian-Mei, WANG Xiao-Hua. Clinical significance of anti-neutrophil cytoplasmic antibodies and anti-endothelial cell antibodies in children with Kawasaki disease[J]. Chinese Journal of Contemporary Pediatrics. 2014, 16(7): 740-744 https://doi.org/10.7499/j.issn.1008-8830.2014.07.017

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