Expression of TGF-β1 and PAI-1 in premature infants with bronchopulmonary dysplasia

ZHANG Jin-Feng; HUNAG Run-Zhong; HUANG Guan-Fen; OU Wei-Ming; LI Jian-Feng; CHEN Jin-Jin

doi:10.7499/j.issn.1008-8830.2014.08.008

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Chinese Journal of Contemporary Pediatrics ›› 2014, Vol. 16 ›› Issue (8) : 810-813. DOI: 10.7499/j.issn.1008-8830.2014.08.008

CLINICAL RESEARCH

Expression of TGF-β1 and PAI-1 in premature infants with bronchopulmonary dysplasia

ZHANG Jin-Feng, HUNAG Run-Zhong, HUANG Guan-Fen, OU Wei-Ming, LI Jian-Feng, CHEN Jin-Jin

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Abstract

Objective To study the expression of transforming growth factor-β1 (TGF-β1) and plasminogen activator inhibitor-1 (PAI-1) and its significance in premature infants with bronchopulmonary dysplasia (BPD). Methods A retrospective analysis was performed on the clinical data of 96 very low birth weight infants (gestational age of ≤32 weeks) who survived for more than 28 days and were admitted to the Neonatal Intensive Care Unit between January 2010 and December 2012. These subjects were divided into BPD group (n=21) and non-BPD group (n=75). The expression of TGF-β1 and PAI-1 in blood was measured by ELISA. Results The levels of TGF-β1 and PAI- 1 in the BPD group increased gradually from the 7th day to the 14th day and then to the 21st day after birth, and were significantly higher than in the non-BPD group at all time points (P<0.01). The TGF-β1 and PAI-1 levels in the non-BPD group on the 7th, 14th, and 21st days after birth were not significantly different from each other (P>0.05). Conclusions The expression of TGF-β1 and PAI-1 in blood is elevated in premature infants with BPD, which may be associated with the development of BPD.

Key words

Bronchopulmonary dysplasia / Transforming growth factor-β1 / Plasminogen activator inhibitor-1 / Premature infant

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ZHANG Jin-Feng, HUNAG Run-Zhong, HUANG Guan-Fen, OU Wei-Ming, LI Jian-Feng, CHEN Jin-Jin. Expression of TGF-β1 and PAI-1 in premature infants with bronchopulmonary dysplasia[J]. Chinese Journal of Contemporary Pediatrics. 2014, 16(8): 810-813 https://doi.org/10.7499/j.issn.1008-8830.2014.08.008

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