[1] Hoffman JI, Kaplan S. The incidence of congenital heartdisease[J]. J Am Coll Cardiol, 2002, 39(12): 1890-1900.
[2] 中华人民共和国国家卫生和计划生育委员会. 中国出生缺陷防治报告(2012). [DB/OL] (2012-09-12) http://www.gov.cn/gzdt/att/att/site1/20120912/1c6f6506c7f811bacf9301.pdf.
[3] Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, andfunction[J]. Cell, 2004, 116(2): 281-297.
[4] Yates LA, Norbury CJ, Gilbert RJ. The long and short ofmicroRNA[J]. Cell, 2013, 153(3): 516-519.
[5] Ikeda S, Kong SW, Lu J, et al. Altered microRNA expression inhuman heart disease[J]. Physiol Genomics, 2007, 31(3): 367-373.
[6] Kumarswamy R, Thum T. Non-coding RNAs in cardiac remodeling and heart failure[J]. Circ Res, 2013, 113(6): 676-689.
[7] Kim GH. MicroRNA regulation of cardiac conduction andarrhythmias[J]. Transl Res, 2013, 161(5): 381-392.
[8] Pan W, Zhong Y, Cheng C, et al. MiR-30-regulated autophagymediates angiotensin II-induced myocardial hypertrophy[J].PLoS One, 2013, 8(1): e53950.
[9] Zhao Y, Ransom JF, Li A, et al. Dysregulation of cardiogenesis,cardiac conduction, and cell cycle in mice lacking miRNA-1-2[J]. Cell, 2007, 129(2): 303-317.
[10] Boettger T, Braun T. A new level of complexity: the role ofmicroRNAs in cardiovascular development[J]. Circ Res, 2012,110(7): 1000-1013.
[11] Zeng Y, Yi R, Cullen BR. Recognition and cleavage of primarymicroRNA precursors by the nuclear processing enzymeDrosha[J]. EMBO J, 2005, 24(1): 138-148.
[12] Faller M, Toso D, Matsunaga M, et al. DGCR8 recognizesprimary transcripts of microRNAs through highly cooperativebinding and formation of higher-order structures[J]. RNA, 2010,16(8): 1570-1583.
[13] Barr I, Smith AT, Senturia R, et al. DiGeorge critical region 8(DGCR8) is a double-cysteine-ligated heme protein[J]. J BiolChem, 2011, 286(19): 16716-16725.
[14] Chakravarthy S, Sternberg SH, Kellenberger CA, et al.Substrate-specific kinetics of dicer-catalyzed RNA processing[J].J Mol Biol, 2010, 404(3): 392-402.
[15] Haase AD, Jaskiewicz L, Zhang HD, et al. TRBP, a regulator ofcellular PKR and HIV-1 virus expression, interacts with Dicerand functions in RNA silencing[J]. EMBO Rep, 2005, 6(10):961-967.
[16] Chen J, Wang DZ. microRNAs in cardiovasculardevelopment[J]. J Mol Cell Cardiol, 2012, 52(5): 949-957.
[17] Huang ZP, Chen JF, Regan JN, et al. Loss of microRNAs inneural crest leads to cardiovascular syndromes resemblinghuman congenital heart defects[J]. Arterioscler Thromb VascBiol, 2010, 30(12): 2575-2586.
[18] Ambros V. The functions of animal microRNAs[J]. Nature,2004, 431(7006): 350-355.
[19] Hashimoto Y, Akiyama Y, Yuasa Y. Multiple-to-multiplerelationships between microRNAs and target genes in gastriccancer[J]. PLoS One, 2013, 8(5): e62589.
[20] Liu N, Olson EN. MicroRNA regulatory networks incardiovascular development[J]. Dev Cell, 2010, 18(4): 510-525.
[21] Chen JF, Mandel EM, Thomson JM, et al. The role ofmicroRNA-1 and microRNA-133 in skeletal muscle proliferationand differentiation[J]. Nat Genet, 2006, 38(2): 228-233.
[22] Li J, Cao Y, Ma XJ, et al. Roles of miR-1-1 and miR-181c inventricular septal defects[J]. Int J Cardiol, 2013, 168(2): 1441-1446.
[23] Akiyama H, Chaboissier MC, Behringer RR, et al. Essential roleof Sox9 in the pathway that controls formation of cardiac valvesand septa[J]. Proc Natl Acad Sci U S A, 2004, 101(17): 6502-6507.
[24] Sanchez-Castro M, Gordon CT, Petit F, et al. Congenital heartdefects in patients with deletions upstream of SOX9[J]. HumMutat, 2013, 34(12): 1628-1631.
[25] Yang B, Lin H, Xiao J, et al. The muscle-specific microRNAmiR-1 regulates cardiac arrhythmogenic potential by targetingGJA1 and KCNJ2[J]. Nat Med, 2007, 13(4): 486-491.
[26] Beppu H, Malhotra R, Beppu Y, et al. BMP type II receptorregulates positioning of outflow tract and remodeling ofatrioventricular cushion during cardiogenesis[J]. Dev Biol,2009, 331(2): 167-175.
[27] Ma LJ, Lu MF, Schwartz RJ, et al. Bmp2 is essential for cardiaccushion epithelial-mesenchymal transition and myocardialpatterning[J]. Development, 2005, 132(24): 5601-5611.
[28] O'Brien JE Jr, Kibiryeva N, Zhou XG, et al. Noncoding RNAexpression in myocardium from infants with tetralogy ofFallot[J]. Circ Cardiovasc Genet, 2012, 5(3): 279-286.
[29] Chinchilla A, Lozano E, Daimi H, et al. MicroRNA profilingduring mouse ventricular maturation: a role for miR-27modulating Mef2c expression[J]. Cardiovasc Res, 2011, 89(1):98-108.
[30] Wang J, Song Y, Zhang Y, et al. Cardiomyocyte overexpressionof miR-27b induces cardiac hypertrophy and dysfunction inmice[J]. Cell Res, 2012, 22(3): 516-527.
[31] Huang X, Huang F, Yang D, et al. Expression of microRNA-122contributes to apoptosis in H9C2 myocytes[J]. J Cell Mol Med,2012, 16(11): 2637-2646.
[32] Zhang HS, Wu QY, Xu M, et al. Mitogen-activated proteinkinase signal pathways play an important role in right ventricularhypertrophy of tetralogy of Fallot[J]. Chin Med J (Engl), 2012,125(13): 2243-2249.
[33] 徐洁, 杨中州, 张姝, 等. 先天性心脏病胎儿心脏及胎盘组织中MAPK 及 Akt 信号通路分子的变化[J]. 中国当代儿科杂志, 2010, 12(5): 327-332.
[34] Brown RD, Ambler SK, Li M, et al. MAP kinase kinasekinase-2 (MEKK2) regulates hypertrophic remodeling of theright ventricle in hypoxia-induced pulmonary hypertension[J].Am J Physiol Heart Circ Physiol, 2013, 304(2): H269-H281.
[35] Nigam V, Sievers HH, Jensen BC, et al. Altered microRNAsin bicuspid aortic valve: a comparison between stenotic andinsufficient valves[J]. J Heart Valve Dis, 2010, 19(4): 459-465.
[36] Kaden JJ, Bickelhaupt S, Grobholz R, et al. Expression of bonesialoprotein and bone morphogenetic protein-2 in calcific aorticstenosis[J]. J Heart Valve Dis, 2004, 13(4): 560-566.
[37] Yu ZB, Han SP, Bai YF, et al. microRNA expression profilingin fetal single ventricle malformation identified by deepsequencing[J]. Int J Mol Med, 2012, 29(1): 53-60.
[38] Liu YG, Huang TW, Zhao XL, et al. MicroRNAs modulatethe Wnt signaling pathway through targeting its inhibitors[J].Biochem Biophys Res Commun, 2011, 408(2): 259-264.
[39] Kuhn DE, Nuovo GJ, Martin MM, et al. Human chromosome21-derived miRNAs are overexpressed in down syndrome brainsand hearts[J]. Biochem Biophys Res Commun, 2008, 370(3):473-477.
[40] Liu N, Bezprozvannaya S, Williams AH, et al. microRNA-133aregulates cardiomyocyte proliferation and suppresses smoothmuscle gene expression in the heart[J]. Genes Dev, 2008,22(23): 3242-3254.
[41] Nagy A. Cre recombinase: the universal reagent for genometailoring[J]. Genesis, 2000, 26(2): 99-109.