Objective To study the expression profile and significance of serum transforming growth factor-beta 1 (TGF-β1) and bone morphogenetic protein-7 (BMP-7) in preterm infants with respiratory distress syndrome (RDS). Methods Thirty-two preterm infants with RDS who were given pulmonary surfactant (PS) within 12 hours after birth were enrolled as the PS group. Twenty-eight preterm infants with RDS who were not given PS were selected as the non-PS group. Another 30 preterm infants without RDS were used as the control group. Serum levels of TGF-β1 and BMP-7 in the three groups were measured using enzyme-linked immunosorbent assay at 0, 1, 3, and 7 days after birth. Results The PS group had higher serum levels of TGF-β1 than the control group at 1 and 3 days after birth (P<0.05). The non-PS group had significantly higher serum levels of TGF-β1 than the control group at 1, 3, and 7 days after birth (P<0.05), and serum levels of TGF-β1 in the non-PS group were significantly higher than the PS group at 3 and 7 days after birth (P<0.05). The PS group had higher serum levels of BMP-7 than the control group at 1 and 3 days after birth (P<0.05). The non-PS group had higher serum levels of BMP-7 than the control group at 1, 3, and 7 days after birth (P<0.05). The levels of BMP-7 in the non-PS group at 7 days after birth were reduced than before, but were still higher than in the PS group (P<0.05). Conclusions Both serum TGF-β1 and BMP-7 levels increase in the early stage in preterm infants with RDS, however, in the late stage, the expresssion of BMP-7 decreases with the increase in TGF-β1 expression, suggesting that administration of exogenous BMP-7 may reduce the expression of TGF-β1, which might be a therapeutic approach for RDS in preterm infants.
Key words
Respiratory distress syndrome /
Bone morphogenetic protein-7 /
Transforming growth factor-β1 /
Preterm infant
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] Kamath BD, Macquire ER, McClure EM, et al. Neonatal mortality from respiratory distress syndrome: lessons for low-resource countries[J]. Pediatrics, 2011, 127(6): 1139-1146.
[2] Ma L, Liu C, Wang Y, et al. Mortality of neonatal respiratory failure related to socioeconomic factors in Hebei province of China[J]. Neonatology, 2011, 100(1): 14-22.
[3] Ruegger C, Hegglin M, Adams M, et al. Swiss Neonatal Network. Population based trends in mortality, morbidity and treatment for very preterm-and very low birth weight infants over 12 years[J]. BMC Pediatr, 2012, 12: 17.
[4] 早产儿支气管肺发育不良调查协作组. 早产儿支气管肺发育不良发生率及高危因素的多中心回顾调查分析[J]. 中华儿科杂志, 2011, 49(9): 655-662.
[5] Sezer RG, Aydemir G, Bozaykut A, et al. The relationship between the first episode of wheezing and matrix metalloproteinases-9 and MMP-2 and tissue inhibitors of MMP-1 levels in preterm infants[J]. Ann Thorac Med, 2013, 4(8): 209-213.
[6] Patel AS, Song JW, Chu SG, et al. Epithelial cell mitochondrial dysfunction and PINK1 are induced by transforming growth factor-beta1 in pulmonary fibrosis[J]. PLoS One, 2015, 10(3): e0121246.
[7] 富建华, 杨海萍, 潘丽, 等. TGF-β1影响肺成纤维细胞结缔组织生长因子基因表达的研究[J]. 中国当代儿科杂志, 2011, 13(1): 36-39.
[8] Stumm CL, Halcsik E, Landgraf RG, et al. Lung remodeling in a mouse model of asthma involves a balance between TGF-β1 and BMP-7[J]. PLoS One, 2014, 9(4): e95959.
[9] 邵晓梅, 叶鸿瑁, 丘小汕. 实用新生儿学[M]. 第四版. 北京: 人民卫生出版社, 2004: 421-427.
[10] Sharon LP. Prolonged mechanical ventilation in children[J]. Pediatr Clin North Am, 1994, 41(3): 473-512.
[11] Britt RD Jr, Velten M, Tipple TE, et al. Cyclooxygenase-2 in newborn hyperoxic lung injury [J]. Free Radic Biol Med, 2013, 61C(8): 502-511.
[12] Gaede KI, Amicosante M, Schurmann M, et al. Function associated transforming growth factor-beta gene polymorphism in chronic beryllium disease[J]. J Mol Med, 2005, 83(5): 397-405.
[13] 刘冬云, 吴静, 张小英,等. 支气管肺发育不良新生儿支气管肺泡灌洗液IL-8、SPA 和TGF-β1的表达[J]. 中国当代儿科杂志, 2010, 12(6): 444-446.
[14] Shimasaki S, Moore RK. Ootsuka F, et al. The bone morphogenetic protein system in mammalian reproduction[J]. Endocrine Rev, 2004, 25(1): 72-101.
PDF(1204 KB)
