Association between anxiety-depression and 5-HTTLPR gene polymorphism in school-aged twins

ZHAO Qiao; LI Yu-Ling; Enherbayaer; LIU Yan; DING Yi

doi:10.7499/j.issn.1008-8830.2016.01.013

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Chinese Journal of Contemporary Pediatrics ›› 2016, Vol. 18 ›› Issue (1) : 61-66. DOI: 10.7499/j.issn.1008-8830.2016.01.013

CLINICAL RESEARCH

Association between anxiety-depression and 5-HTTLPR gene polymorphism in school-aged twins

ZHAO Qiao, LI Yu-Ling, Enherbayaer, LIU Yan, DING Yi

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Abstract

Objective To investigate the association between anxiety-depression and 5-HTTLPR gene polymorphism in school-aged twins. Methods A total of 147 pairs of twins (47 pairs of monozygotic twins, 100 pairs of dizygotic twins) aged 8-12 years from Baotou and Hohhot were selected as respondents. The Achenbach Child Behavior Checklist (CBCL) was used to calculate the scores of anxiety-depression factors in school-aged twins. The DNA was extracted from oral epithelial cells, and polymerase chain reaction was applied for 5-HTTLPR genotyping. The generalized estimating equation (GEE) was used to analyze the effect of 5-HTTLPR polymorphism and family environment on anxiety-depression in school-aged twins. Results The children with LS and SS genotypes had significantly higher scores of anxiety-depression factors than those with LL genotype (χ²=3.938, P<0.05). The interaction of 5-HTTLPR genotype with family cohesion and family rearing patterns had a significant impact on the scores of anxiety-depression factors in twins (χ²=6.129 and 7.665, both P<0.05). Conclusions 5-HTTLPR genotype is significantly correlated with the scores of anxiety-depression factors in school-aged twins. In the family with high cohesion and an autocratic family rearing pattern, S allele may increase the possibility of anxiety-depression in twin children.

Key words

Anxiety-depression / 5-HTTLPR polymorphism / School-aged twins

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ZHAO Qiao, LI Yu-Ling, Enherbayaer, LIU Yan, DING Yi. Association between anxiety-depression and 5-HTTLPR gene polymorphism in school-aged twins[J]. Chinese Journal of Contemporary Pediatrics. 2016, 18(1): 61-66 https://doi.org/10.7499/j.issn.1008-8830.2016.01.013

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