Risk factors for hearing impairment induced by cytomegalovirus infection

ZHANG Mei-Juan; YUAN Tian-Ming; WANG Li-Zhen

doi:10.7499/j.issn.1008-8830.2016.03.007

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Chinese Journal of Contemporary Pediatrics ›› 2016, Vol. 18 ›› Issue (3) : 224-228. DOI: 10.7499/j.issn.1008-8830.2016.03.007

CLINICAL RESEARCH

Risk factors for hearing impairment induced by cytomegalovirus infection

ZHANG Mei-Juan^1,2, YUAN Tian-Ming¹, WANG Li-Zhen²

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Abstract

Objective To investigate the risk factors for hearing impairment induced by cytomegalovirus (CMV) infection in children. Methods One hundred and fifty-eight children diagnosed with CMV infection were enrolled as subjects. Based on the results of the brainstem auditory evoked potential (BAEP) test, patients were classified into normal hearing group (n=117; BAEP ≤35) and abnormal hearing group (n=41; BAEP >35). A retrospective analysis was performed on the general information, routine blood indices, liver function, copy number of CMV-DNA in urine and breast milk. The receiver operating characteristic (ROC) curve was used to predict the copy number of CMV-DNA resulting in abnormal BAEP. The Spearman rank correlation analysis was used to test the correlations of the copy number of CMV-DNA in urine with the degree of hearing impairment and platelet count. Results The incidence rates of platelet abnormality and abnormal liver function and the copy number of CMV-DNA in urine were significantly higher in the abnormal hearing group than in the normal hearing group (P<0.01). According to the ROC curve, the copy number of CMV-DNA in urine had a sensitivity of 46.3% and a specificity of 93.2% in predicting hearing impairment when it reached 1.415×10⁶ per mL. The results of correlation analysis showed that the degree of hearing impairment was positively correlated with the copy number of CMV-DNA (r=0.382, P<0.01); the platelet count was negatively correlated with the copy number of CMV-DNA in urine (r=-0.233, P=0.003). Conclusions An increased copy number of CMV-DNA in urine might be a risk factor for hearing impairment induced by CMV infection. Children are likely to have hearing impairment when the copy number of CMV-DNA reaches 1.415×10⁶ per mL. The monitoring of hearing should be strengthened in CMV-infected children with a decreased platelet count.

Key words

Cytomegalovirus infection / Brainstem auditory evoked potential / Hearing impairment / Child

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ZHANG Mei-Juan, YUAN Tian-Ming, WANG Li-Zhen. Risk factors for hearing impairment induced by cytomegalovirus infection[J]. Chinese Journal of Contemporary Pediatrics. 2016, 18(3): 224-228 https://doi.org/10.7499/j.issn.1008-8830.2016.03.007

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