Abstract Objective To investigate the efficacy of oral sweet solutions in relieving pain caused by vaccination in infants aged 1 to 12 months. Methods Related databases were searched to find related randomized control trails (RCTs). The quality of these RCTs was evaluated. The Meta analysis was performed using RevMan 5.3. Results A total of 20 RCTs involving 2 376 infants were included, and quality assessment showed that 6 RCTs had grade A quality and 14 had grade B quality. The Meta analysis showed that compared with sterile water, 25%-75% oral sweet solution significantly reduced crying time (WMD = -21.16, 95%CI -39.66 to -2.77, P < 0.05) and the proportion of crying time (the duration of crying /3-minute periods after the injection) (WMD = -13.83, 95%CI -20.88 to -6.78, P < 0.01), while the crying time showed no significant difference between the group treated with oral administration of 12% sucrose solution and non-intervention group. Conclusions Oral sweet solution (25%-75%; 2 mL) given 2 minutes before vaccination can effectively relieve the pain caused by vaccination in infants aged 1-12 months.
CHEN Shao-Lin,Harrison Denise,HUANG Rui-Rui et al. Efficacy of sweet solutions in relieving pain caused by vaccination in infants aged 1 to 12 months: a systematic review[J]. CJCP, 2016, 18(6): 534-540.
CHEN Shao-Lin,Harrison Denise,HUANG Rui-Rui et al. Efficacy of sweet solutions in relieving pain caused by vaccination in infants aged 1 to 12 months: a systematic review[J]. CJCP, 2016, 18(6): 534-540.
WHO. Vaccine-preventable diseases and vaccines.[2016-3-24]
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