Abstract The gastrointestinal structure, function and immunity of preterm infants are immature. Furthermore the gastrointestinal microbe colonization is abnormal. Therefore the preterm infants are prone to a variety of gastrointestinal diseases. Probiotics can regulate gastrointestinal microbe constitute, improve gastrointestinal barrier function, reduce gastrointestinal inflammation response and regulate the immunity. At present, it is used for the prevention of necrotizing enterocolitis, late-onset sepsis, and feeding intolerance. The safety and efficacy of probiotics for preterm infants are still controversial.
Millar MR, Bacon C, Smith SL, et al. Enteral feeding of premature infants with Lactobacillus GG[J]. Arch Dis Child, 1993, 69(5 Spec No):483-487.
[2]
Deshpande G, Rao S, Patole S. Probiotics in neonatal intensive care-back to the future[J]. Aust N Z J Obstet Gynaecol, 2015, 55(3):210-217.
[3]
Fanaro S. Feeding intolerance in the preterm infant[J]. Early Hum Dev, 2013, 89(2):S13-S20.
[4]
Choi YY. Necrotizing enterocolitis in newborns:update in pathophysiology and newly emerging therapeutic strategies[J]. Korean J Pediatr, 2014, 57(12):505-513.
[5]
Patel RM, Denning PW. Therapeutic use of prebiotics, probiotics and postbiotics to prevent necrotizing enterocolitis:what is the current evidence?[J]. Clin Perinatol, 2013, 40(1):11-25.
[6]
Arboleya S, Binetti A, Salazar N, et al. Establishment and development of intestinal microbiota in preterm neonates[J]. FEMS Microbiol Ecol, 2012, 79(3):763-772.
[7]
Di Gioia D, Aloisio I, Mazzola G, et al. Bifidobacteria:their impact on gut microbiota composition and their applications as probiotics in infants[J]. Appl Microbiol Biotechnol, 2014, 98(2):563-577.
[8]
Arboleya S, Solís G, Fernández N, et al. Facultative to strict anaerobes ratio in the preterm infant microbiota:a target for intervention[J]. Gut Microbes, 2012, 3(6):583-588.
[9]
Grishin A, Bowling J, Bell B, et al. Roles of nitric oxide and intestinal Microbiota in the pathogenesis of necrotizing enterocolitis[J]. J Pediatr Surg, 2016, 51(1):13-17.
[10]
Berrington JE, Stewart CJ, Cummings SP, et al. The neonatal bowel microbiome in health and infection[J]. Curr Opin Infect Dis, 2014, 27(3):236-243.
[11]
DiBartolomeo ME, Claud EC. The developing microbiome of the preterm infant[J]. Clin Ther, 2016, 38(4):733-739.
[12]
Jakaitis BM, Denning PW. Commensal and probiotic bacteria may prevent NEC by maturing intestinal host defenses[J]. Pathophysiology, 2014, 21(1):47-54.
[13]
Havranek T, Al-Hosni M, Armbrecht E. Probiotics supplementation increases intestinal blood flow velocity in extremely low birth weight preterm infants[J]. J Perinatol, 2013, 33(1):40-44.
[14]
Braga TD, da Silva GA, de LiraPI, et al. Efficacy of Bifidobacterium breve and Lactobacillus casei oral supplementation on necrotizing enterocolitis in very-low-birth-weight preterm infants:a double-blind, randomized, controlled trial[J]. Am J Clin Nutr, 2011, 93(1):81-86.
[15]
Yang Y, Guo Y, Kan Q, et al. A meta-analysis of probiotics for preventing necrotizing enterocolitis in preterm neonates[J]. Braz J Med Biol Res, 2014, 47(9):804-810.
[16]
Anderson S. Probiotics for preterm infants:a premature or overdue necrotizing enterocolitis prevention strategy?[J]. Neonatal Netw, 2015, 34(2):83-101.
[17]
Al-Hosni M, Duenas M, Hawk M, et al. Probioticssupplemented feeding in extremely low-birth-weight infants[J]. J Perinatol, 2012, 32(4):253-259.
[18]
Olsen R, Greisen G, Schrøder M, et al. Prophylactic probiotics for preterm infants:a systematic review and meta-analysis of observational studies[J]. Neonatology, 2016, 109(2):105-112.
[19]
Lau CS, Chamberlain RS. Probiotic administration can prevent necrotizing enterocolitis in preterm infants:a meta-analysis[J]. J Pediatr Surg, 2015, 50(8):1405-1412.
[20]
Sari FN, Dizdar EA, Oguz S, et al. Oral probiotics:Lactobacillus sporogenes for prevention of necrotizing enterocolitis in very low-birth weight infants:a randomized, controlled trial[J]. Eur J Clin Nutr, 2011, 65(4):434-439.
[21]
Totsu S, Yamasaki C, Terahara M, et al. Bifidobacterium and enteral feeding in preterm infants:cluster-randomized trial[J]. Pediatr Int, 2014, 56(5):714-719.
[22]
Demirel G, Celik IH, Erdeve O, et al. Prophylactic Saccharomyces boulardii versus nystatin for the prevention of fungal colonization and invasive fungal infection in premature infants[J]. Eur J Pediatr, 2013, 172(10):1321-1326.
[23]
Jacobs SE, Tobin JM, Opie GF, et al. Probiotic effects on lateonset sepsis in very preterm infants:a randomized controlled trial[J]. Pediatrics, 2013, 132(6):1055-1062.
[24]
Lin HC, Su BH, Chen AC, et al. Oral probiotics reduce the incidence and severity of necrotizing enterocolitis in very low birth weight infants[J]. Pediatrics, 2005, 115(1):1-4.
[25]
Kanic Z, Micetic Turk D, Burja S, et al. Influence of a combination of probiotics on bacterial infections in very low birth weight newborns[J]. Wien Klin Wochenschr, 2015, 127(5):210-215.
[26]
Tewari VV, Dubey SK, Gupta G. Bacillus clausii for prevention of late-onset sepsis in preterm infants:a randomized controlled Trial[J]. J Trop Pediatr, 2015, 61(5):377-385.
[27]
Oncel MY, Arayici S, Sari FN, et al. Comparison of Lactobacillus reuteri and nystatin prophylaxis on Candida colonization and infection in very low birth weight infants[J]. J Matern Fetal Neonatal Med, 2015, 28(15):1790-1794.
[28]
Athalye-Jape G, Deshpande G, Rao S, et al. Benefits of probiotics on enteral nutrition in preterm neonates:a systematic review[J]. Am J Clin Nutr, 2014, 100(6):1508-1519.
[29]
Demirel G, Erdeve O, Celik IH, et al. Saccharomyces boulardii for prevention of necrotizing enterocolitis in preterm infants:a randomized, controlled study[J]. Acta Paediatr, 2013, 102(12):e560-e565.
[30]
Yamasaki C, Totsu S, Uchiyama A, et al. Effect of Bifidobacterium administration on very-low-birth weight infants[J]. Pediatr Int, 2012, 54(5):651-656.
[31]
Fernández-Carrocera LA, Solis-Herrera A, Cabanillas-Ayón M, et al. Double-blind, randomised clinical assay to evaluate the efficacy of probiotics in preterm newborns weighing less than 1500 g in the prevention of necrotising enterocolitis[J]. Arch Dis Child Fetal Neonatal Ed, 2013, 98(1):F5-9.
[32]
Romeo MG, Romeo DM, Trovato L, et al. Role of probiotics in the prevention of the enteric colonization by Candida in preterm newborns:incidence of late-onset sepsis and neurological outcome[J]. J Perinatol, 2011, 31(1):63-69.
[33]
Roy A, Chaudhuri J, Sarkar D, et al. Role of enteric supplementation of probiotics on late-onset sepsis by Candida species in preterm low birth weight neonates:a randomized, double blind, placebo-controlled trial[J]. N Am J Med Sci, 2014, 6(1):50-57.
[34]
Agrawal S, Rao S, Patole S. Probiotic supplementation for preventing invasive fungal infections in preterm neonates-a systematic review and meta-analysis[J]. Mycoses, 2015, 58(11):642-651.
[35]
Bertelsen RJ, Jensen ET, Ringel-Kulka T. Use of probiotics and prebiotics in infant feeding[J]. Best Pract Res Clin Gastroenterol, 2016, 30(1):39-48.
[36]
Lambæk ID, Fonnest G, Gormsen M, et al. Probiotics to prevent necrotising enterocolitis in very preterm infants[J]. Dan Med J, 2016, 63(3).pii:A5203.
[37]
Dani C, Coviello CC, Corsini Ⅱ, et al. Lactobacillus sepsis and probiotic therapy in newborns:two new cases and literature review[J]. AJP Rep, 2016, 6(1):e25-e29.
[38]
Zbinden A, Zbinden R, Berger C, et al. Case series of Bifidobacterium longum Bacteremia in three preterm infants on probiotic therapy[J]. Neonatology, 2015, 107(1):56-59.
[39]
Lin HC, Hsu CH, Chen HL, et al. Oral probiotics prevent necrotizing enterocolitis in very low birth weight preterm infants:a multicenter, randomized, controlled trial[J]. Pediatrics, 2008, 122(4):693-700.
[40]
Millar M, Wilks M, Fleming P, et al. Should the use of probiotics in the preterm be routine?[J]. Arch Dis Child Fetal Neonatal Ed, 2012, 97(1):F70-F74.
[41]
Szajewska H, van Goudoever JB. To give or not to give probiotics to preterm infants[J]. Am J Clin Nutr, 2014, 100(6):1411-1412.
