Abstract Objective Childhood malnutrition is an important disease threatening healthy growth of children worldwide. Gut microbiota has close links to food digestion, absorption and intestinal function. Current research considers that alterations in gut microbiota have been strongly implicated in childhood malnutrition. This review article addresses the latest understanding and evidence of interrelationship between gut microbiota and individual nutrition status, the changes of gut microbiota in different types of malnutrition, and the attribution of gut microbiota in the treatment and prognosis of malnutrition. It provides in depth understanding of childhood malnutrition from the perspective of microbiome.
WANG Hui-Hui,WEN Fei-Qiu,WEI Ju-Rong. Research advances in the relationship between childhood malnutrition and gut microbiota[J]. CJCP, 2016, 18(11): 1188-1193.
WANG Hui-Hui,WEN Fei-Qiu,WEI Ju-Rong. Research advances in the relationship between childhood malnutrition and gut microbiota[J]. CJCP, 2016, 18(11): 1188-1193.
Dewey KG,Begum K.Long-term consequences of stunting in early life[J].Matern Child Nutr,2011,7 Suppl 3:5-18.
[2]
Bhutta ZA,Ahmed T,Black RE,et al.What works? Interventions for maternal and child undernutrition and survival[J].Lancet,2008,371(9610):417-440.
[3]
Black RE,Victora CG,Walker SP,et al.Maternal and child undernutrition and overweight in low-income and middleincome countries[J].Lancet,2013,382(9890):427-451.
[4]
Kau AL,Ahern PP,Griffin NW,et al.Human nutrition,the gut microbiome and the immune system[J].Nature,2011,474(7351):327-336.
[5]
Gordon JI,Dewey KG,Mills DA,et al.The human gut microbiota and undernutrition[J].Sci Transl Med,2012,4(137):137ps12.
[6]
World health organization.WHO Anthro (version 3.2.2,January 2011) and macros[EB/OL].(2011-01)[2016-05-12].
[7]
Prentice AM,Nabwera H,Kwambana B,et al.Microbes and the malnourished child[J].Sci Transl Med,2013,5(180):180fs11.
[8]
Turnbaugh PJ,Ley RE,Mahowald MA,et al.An obesityassociated gut microbiome with increased capacity for energy harvest[J].Nature,2006,444(7122):1027-1031.
[9]
Turnbaugh PJ,Hamady M,Yatsunenko T,et al.A core gut microbiome in obese and lean twins[J].Nature,2009,457(7228):480-484.
[10]
Krajmalnik-Brown R,Ilhan ZE,Kang DW,et al.Effects of gut microbes on nutrient absorption and energy regulation[J].Nutr Clin Pract,2012,27(2):201-214.
[11]
Xiong Y,Miyamoto N,Shibata K,et al.Short-chain fatty acids stimulate leptin production in adipocytes through the G proteincoupled receptor GPR41[J].Proc Natl Acad Sci U S A,2004,101(4):1045-1050.
[12]
Maslowski KM,Vieira AT,Ng A,et al.Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43[J].Nature,2009,461(7268):1282-1286.
[13]
Hong YH,Nishimura Y,Hishikawa D,et al.Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43[J].Endocrinology,2005,146(12):5092-5099.
[14]
Round JL,Mazmanian SK.The gut microbiota shapes intestinal immune responses during health and disease[J].Nat Rev Immunol,2009,9(5):313-323.
[15]
Lupp C,Robertson ML,Wickham ME,et al.Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae[J].Cell Host&Microbe,2007,2(3):204.
[16]
Ahmed T,Auble D,Berkley JA,et al.An evolving perspective about the origins of childhood undernutrition and nutritional interventions that includes the gut microbiome[J].Ann N Y Acad Sci,2014,1332:22-38.
[17]
Kane AV,Dinh DM,Ward HD.Childhood malnutrition and the intestinal microbiome[J].Pediatr Res,2015,77(1-2):256-262.
[18]
Lozupone CA,Stombaugh JI,Gordon JI,et al.Diversity,stability and resilience of the human gut microbiota[J].Nature,2012,489(7415):220-230.
[19]
Million M,Diallo A,Raoult D.Gut microbiota and malnutrition[J].Microb Pathog,2016.[Epub ahead of print]
[20]
Kameyama K,Itoh K.Intestinal colonization by a Lachnospiraceae bacterium contributes to the development of diabetes in obese mice[J].Microbes Environ,2014,29(4):427-430.
[21]
Yatsunenko T,Rey FE,Manary MJ,et al.Human gut microbiome viewed across age and geography[J].Nature,2012,486(7402):222-227.
[22]
Gura T.Nature's first functional food[J].Science,2014,345(6198):747-749.
[23]
Monira S,Nakamura S,Gotoh K,et al.Gut microbiota of healthy and malnourished children in bangladesh[J].Front Microbiol,2011,2:228.
[24]
Gupta SS,Mohammed MH,Ghosh TS,et al.Metagenome of the gut of a malnourished child[J].Gut Pathog,2011,3:7.
[25]
Wu GD,Chen J,Hoffmann C,et al.Linking long-term dietary patterns with gut microbial enterotypes[J].Science,2011,334(6052):105-108.
[26]
Smith MI,Yatsunenko T,Manary MJ,et al.Gut microbiomes of Malawian twin pairs discordant for kwashiorkor[J].Science,2013,339(6119):548-554.
[27]
Trehan I,Goldbach HS,LaGrone LN,et al.Antibiotics as part of the management of severe acute malnutrition[J].N Engl J Med,2013,368(5):425-435.
[28]
Subramanian S,Huq S,Yatsunenko T,et al.Persistent gut microbiota immaturity in malnourished Bangladeshi children[J].Nature,2014,510(7505):417-421.
[29]
Blanton LV,Charbonneau MR,Salih T,et al.Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children[J].Science,2016,351(6275):1-18.
[30]
Subramanian S,Blanton LV,Frese SA,et al.Cultivating healthy growth and nutrition through the gut microbiota[J].Cell,2015,161(1):36-48.
[31]
Pennisi E.Microbiome.The right gut microbes help infants grow[J].Science,2016,351(6275):802.
[32]
Unicef India.Nutrition[EB/OL].[2016-05-12].
[33]
Rehman AM,Gladstone BP,Verghese VP,et al.Chronic growth faltering amongst a birth cohort of Indian children begins prior to weaning and is highly prevalent at three years of age[J].Nutr J,2009,8:44.
[34]
Larnkjaer A,Molgaard C,Michaelsen KF.Early nutrition impact on the insulin-like growth factor axis and later health consequences[J].Curr Opin Clin Nutr Metab Care,2012,15(3):285-292.
[35]
de Onis M,Blossner M,Borghi E.Prevalence and trends of stunting among pre-school children,1990-2020[J].Public Health Nutr,2012,15(1):142-148.
[36]
Ghosh TS,Gupta SS,Bhattacharya T,et al.Gut microbiomes of Indian children of varying nutritional status[J].PLoS One,2014,9(4):e95547.
[37]
Cox LM,Yamanishi S,Sohn J,et al.Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences[J].Cell,2014,158(4):705-721.
[38]
Gough EK,Stephens DA,Moodie EE,et al.Linear growth faltering in infants is associated with Acidaminococcus sp.and community-level changes in the gut microbiota[J].Microbiome,2015,3:24.
[39]
Jumas-Bilak E,Carlier JP,Jean-Pierre H,et al.Acidaminococcus intestini sp.nov.,isolated from human clinical samples[J].Int J Syst Evol Microbiol,2007,57(Pt 10):2314-2319.
[40]
Dai ZL,Li XL,Xi PB,et al.L-Glutamine regulates amino acid utilization by intestinal bacteria[J].Amino acids,2013,45(3):501-512.
[41]
Peterson KM,Buss J,Easley R,et al.REG1B as a predictor of childhood stunting in Bangladesh and Peru[J].Am J Clin Nutr,2013,97(5):1129-1133.
[42]
Korpe PS,Petri WA Jr.Environmental enteropathy:critical implications of a poorly understood condition[J].Trends Mol Med,2012,18(6):328-336.
[43]
Hossain MI,Nahar B,Hamadani JD,et al.Intestinal mucosal permeability of severely underweight and nonmalnourished Bangladeshi children and effects of nutritional rehabilitation[J].J Pediatr Gastroenterol Nutr,2010,51(5):638-644.
[44]
Prendergast A,Kelly P.Enteropathies in the developing world:neglected effects on global health[J].Am J Trop Med Hyg,2012,86(5):756-763.