Abstract Objective To study the association between interleukin-1β (IL-1β) C+3953T and genetic susceptibility to spontaneous preterm birth (SPTB). Methods In this case-control study, 753 SPTB neonates were enrolled in the case group and 681 full-term neonates were enrolled in the control group. The latest Sequenom MassARRAY®SNP detection technique was used for the typing of single nucleotide polymorphisms (SNP) of IL-1β C+3953T. Results Compared with those carrying CC genotype of IL-1β C+3953T, the neonates who carried at least one T allele (CT+TT genotype) had significantly increased risks of SPTB, SPTB complicated by premature rupture of membranes, and mild preterm birth. Conclusions In the Chinese population, IL-1β C+3953T has significant genetic association with an increased risk of SPTB. The identification of this SNP helps to prevent SPTB and clarify the causes and pathogenesis of SPTB.
YANG Xiao,PENG Wei,ZHU Li-Na et al. Association between interleukin-1β C+3953T and genetic susceptibility to spontaneous preterm birth: a case-control study[J]. CJCP, 2016, 18(11): 1123-1129.
YANG Xiao,PENG Wei,ZHU Li-Na et al. Association between interleukin-1β C+3953T and genetic susceptibility to spontaneous preterm birth: a case-control study[J]. CJCP, 2016, 18(11): 1123-1129.
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