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Association between brain-derived neurotrophic factor and severity of asthma in children
FENG Shuai, CHEN Bo, YIN Xiao-Wen, LI Fang-Jun
Chinese Journal of Contemporary Pediatrics ›› 2017, Vol. 19 ›› Issue (2) : 167-170.
PDF(1217 KB)
PDF(1217 KB)
Association between brain-derived neurotrophic factor and severity of asthma in children
Objective To investigate the association between the serum level of brain-derived neurotrophic factor (BDNF) and the severity of asthma in children. Methods A total of 60 children with acute exacerbation of asthma were enrolled and divided according to the severity of the disease into mild group (n=18), moderate group (n=25), and severe group (n=17). Sixty healthy children were enrolled as controls. ELISA was used to measure the serum BDNF level in each group and the association between serum BDNF level and the severity of asthma was analyzed. Results The asthmatic children at the acute exacerbation and remission stages had significantly higher serum BDNF levels than healthy controls (P < 0.05). The serum BDNF level was significantly reduced in the remission stage compared with that in the acute exacerbation stage in asthmatic children (P < 0.05). The children with varying degrees of severity at the acute exacerbation stage had different serum BDNF levels: the severe group had the highest serum BDNF level and the mild group had the lowest level (P < 0.05). Conclusions BDNF may play an important role in the pathogenesis of childhood asthma and is related to the severity of the disease.
Serum brain-derived neurotrophic factor / Asthma / Severity / Child
[1] 刘传合,洪建国,尚云晓,等.中国16城市儿童哮喘患病率20年对比研究[J].中国实用儿科杂志,2015,30(8):596-600.
[2] 李秋根,王爱平,夏莺,等.支气管哮喘大鼠肺内神经营养因子对气道高反应性影响的研究[J].中华神经医学杂志,2012,11(1):31-36.
[3] 吴莎,华清泉,杨琨,等.脑源性神经营养因子研究进展[J].中华临床医师杂志(电子版),2013,7(9):3988-3990.
[4] Prakash YS,Martin RJ.Brain-derived neurotrophic factor in the airways[J].Pharmacol Ther,2014,143(1):74-86.
[5] Yinli C,Jie H,Li Z,et al.Association between brain-derived neurotrophic factor variants and asthma in Chinese Han children[J].Acta Paediatr,2013,102(6):e247-250.
[6] Global initiative for asthma.Global strategy for asthma management and prevention[EB/OL].(2014-5)[2016-7] .http://ginasthma.org/.
[7] Sathish V,Vanoosten SK,Miller BS,et al.Brain-derived neurotrophic factor in cigarette smoke-induced airway hyperreactivity[J].Am J Respir Cell Mol Biol,2013,48(4):431-438.
[8] Stoll P,Wuertemberger U,Bratke K,et al.Stage-dependent association of BDNF and TGF-β1 with lung function in stable COPD[J].Respir Res,2012,13:116.
[9] 冯爽,史瑞明.支气管哮喘相关基因的研究进展[J].国际儿科学杂志,2015,42(2):121-124.
[10] 陈大伟,刘燕青,张朝.脑源性神经营养因子的研究进展[J].北方药学,2015,12(3):110-112.
[11] Ma L,Gao XH,Zhao LP,et al.Brain-derived neurotrophic factor gene polymorphisms and serum levels in Chinese atopic dermatitis patients[J].J Eur Acad Dermatol Venereol,2009,23(11):1277-1281.
[12] Lommatzsch M,Braun A,Renz H.Neurotrophins in allergic airway dysfunction:what the mouse model is teaching US[J].Ann N Y Acad Sci,2003,992:241-249.
[13] 张艳,许秀娟,王伟.支气管哮喘大鼠肺内脑源性神经营养因子和降钙素基因相关肽的表达及布地奈德的干预作用[J].国际呼吸杂志,2015,35(17):1281-1284.
[14] Aravamudan B,Thompson M,Pabelick C,et al.Brain-derived neurotrophic factor induces proliferation of human airway smooth muscle cells[J].J Cell Mol Med,2012,16(4):812-823.
[15] Vohra PK,Thompson MA,Sathish V,et al.TRPC3 regulates release of brain-derived neurotrophic factor from human airway smooth muscle[J].Biochim Biophys Acta,2013,1833(12):2953-2960.
[16] 倪萍,张春玲.支气管哮喘患者血清脑源性神经营养因子含量的变化及其临床意义[J].临床肺科杂志,2008,13(9):1130-1131.
[17] Jeanneteau F,Chao MV.Are BDNF and glucocorticoid activities calibrated[J].Neuroscience,2013,239(23):173-195.
