Advances in genetic research of cerebral palsy

WANG Fang-Fang; LUO Rong; QU Yi; MU De-Zhi

doi:10.7499/j.issn.1008-8830.2017.09.018

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Chinese Journal of Contemporary Pediatrics ›› 2017, Vol. 19 ›› Issue (9) : 1022-1026. DOI: 10.7499/j.issn.1008-8830.2017.09.018

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Advances in genetic research of cerebral palsy

WANG Fang-Fang, LUO Rong, QU Yi, MU De-Zhi

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Abstract

Cerebral palsy is a group of syndromes caused by non-progressive brain injury in the fetus or infant and can cause disabilities in childhood. Etiology of cerebral palsy has always been a hot topic for clinical scientists. More and more studies have shown that genetic factors are closely associated with the development of cerebral palsy. With the development and application of various molecular and biological techniques such as chromosome microarray analysis, genome-wide association study, and whole exome sequencing, new achievements have been made in the genetic research of cerebral palsy. Chromosome abnormalities, copy number variations, susceptibility genes, and single gene mutation associated with the development of cerebral palsy have been identified, which provides new opportunities for the research on the pathogenesis of cerebral palsy. This article reviews the advances in the genetic research on cerebral palsy in recent years.

Key words

Cerebral palsy / Copy number variation / Susceptibility gene / Causative gene / Child

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WANG Fang-Fang, LUO Rong, QU Yi, MU De-Zhi. Advances in genetic research of cerebral palsy[J]. Chinese Journal of Contemporary Pediatrics. 2017, 19(9): 1022-1026 https://doi.org/10.7499/j.issn.1008-8830.2017.09.018

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