Abstract Objective To investigate the influence of pre-pregnancy parental body mass index (BMI), maternal weight gain during pregnancy, and their interaction on neonatal birth weight. Methods A total of 1 127 pregnant women who underwent regular prenatal examinations and full-term singleton delivery in the First Hospital of Xi'an Jiaotong University from January 2017 to October 2018 were enrolled. The data on their pre-pregnancy BMI, maternal weight gain during pregnancy, pre-pregnancy BMI of the husband, and neonatal birth weight were collected. The interaction between pre-pregnancy parental BMI and maternal weight gain during pregnancy was analyzed, and their correlation with neonatal birth weight was analyzed. Results Among the 1 127 full-term neonates, the detection rates of low birth weight neonates and macrosomia were 2.22% (25/1 127) and 3.82% (43/1 127) respectively. There were significant differences in pre-pregnancy parental BMI and maternal weight gain during pregnancy among the low birth weight, normal birth weight, and macrosomia groups (P < 0.05). Neonatal birth weight was positively correlated with pre-pregnancy parental BMI and maternal weight gain during pregnancy (r=0.097-0.322, P < 0.05). Low maternal weight before pregnancy increased the risk of low birth weight (RR=4.17, 95%CI:1.86-9.38), and maternal overweight/obesity before pregnancy (RR=3.59, 95%CI:1.93-6.67) and excessive weight gain during pregnancy (RR=3.21, 95%CI:1.39-7.37) increased the risk of macrosomia. No interaction between pre-pregnancy maternal BMI and maternal weight gain during pregnancy was observed. Conclusions Pre-pregnancy parental BMI and maternal weight gain during pregnancy are related to neonatal birth weight, and there is no interaction between pre-pregnancy maternal BMI and maternal weight gain during pregnancy.
SHI Xiao-Wei,YUE Jie,LYU Min et al. Influence of pre-pregnancy parental body mass index, maternal weight gain during pregnancy, and their interaction on neonatal birth weight[J]. CJCP, 2019, 21(8): 783-788.
SHI Xiao-Wei,YUE Jie,LYU Min et al. Influence of pre-pregnancy parental body mass index, maternal weight gain during pregnancy, and their interaction on neonatal birth weight[J]. CJCP, 2019, 21(8): 783-788.
Gamboa Delgado EM, Rangel-Díaz YA, Gutiérrez-Gómez YY. Association between birth weight and cardiometabolic risk factors in children of Bucaramanga, Colombia[J]. Nutr Hosp, 2017, 34(5):1105-1111.
[3]
Szabelska-Zakrzewska K, Durko A, Socha-Banasiak A, et al. Metabolic syndrome in overweight or obese children and adolescents based on own material Abstract Key words[J]. Dev Period Med, 2018, 22(4):351-357.
Goldstein RF, Abell SK, Ranasinha S, et al. Gestational weight gain across continents and ethnicity:systematic review and meta-analysis of maternal and infant outcomes in more than one million women[J]. BMC Med, 2018, 16(1):153.
[6]
Corsi DJ, Subramanian SV, Ackerson LK, et al. Is there a greater maternal than paternal influence on offspring adiposity in India?[J]. Arch Dis Child, 2015, 100(10):973-979.
[7]
Gómez-López L, Van Hulst A, Barnett TA, et al. Does parental body mass index status modify the associations among birth weight, early growth and childhood adiposity?[J]. Paediatr Child Health, 2013, 18(2):e2-e9.
Zhou A, Xiong C, Hu R, et al. Pre-pregnancy BMI, gestational weight gain, and the risk of hypertensive disorders of pregnancy:a cohort study in Wuhan, China[J]. PLoS One, 2015, 10(8):e0136291.
Goldstein RF, Abell SK, Ranasinha S, et al. Association of gestational weight gain with maternal and infant outcomes:a systematic review and meta-analysis[J]. JAMA, 2017, 317(21):2207-2225.
[13]
Lindsay KL, Brennan L, Rath A, et al. Gestational weight gain in obese pregnancy:impact on maternal and foetal metabolic parameters and birth weight[J]. J Obstet Gynaecol, 2018, 38(1):60-65.
[14]
Zhou Z, Lin Q, Xu X, et al. Maternal high-fat diet impairs follicular development of offspring through intraovarian kisspeptin/GPR54 system[J]. Reprod Biol Endocrinol, 2019, 7(1):13.
[15]
Zhao R, Xu L, Wu ML, et a1. Maternal pre-pregnancy body mass index, gestational weight gain influence birth weight[J]. Women Birth, 2018, 3l(1):e20-e25.
[16]
Richardson BS, Ruttinger S, Brown HK, et al. Maternal body mass index impacts fetal-placental size at birth and umbilical cord oxygen values with implications for regulatory mechanisms[J]. Early Hum Dev, 2017, 112:42-47.
[17]
Demerath EW, Choh AC, Czerwinski SA, et al. Genetic and environmental influences on infant weight and weight change:the Fels Longitudinal Study[J]. Am J Hum Biol, 2007, 19(5):692-702.
[18]
Donkin I, Versteyhe S, Ingerslev LR, et al. Obesity and bariatric surgery drive epigenetic variation of spermatozoa in humans[J]. Cell Metab, 2016, 23(2):369-378.
[19]
Roy SM, Chesi A, Mentch F, et al. Body mass index (BMI) trajectories in infancy differ by population ancestry and may presage disparities in early childhood obesity[J]. J Clin Endocrinol Metab, 2015, 100(4):1551-1560.
Mejia-Lancheros C, Mehegan J, Murrin CM, et al. Smoking habit from the paternal line and grand-child's overweight or obesity status in early childhood:prospective findings from the lifeways cross-generation cohort study[J]. Int J Obes (Lond), 2018, 42(11):1853-1870.
[22]
Jenkins TG, Aston KI, James ER, et al. Sperm epigenetics in the study of male fertility, offspring health, and potential clinical applications[J]. Syst Biol Reprod Med, 2017, 63(2):69-76.
[23]
Linabery AM, Nahhas RW, Johnson W, et al. Stronger influence of maternal than paternal obesity on infant and early childhood body mass index:the Fels Longitudinal Study[J]. Pediatr Obes, 2013, 8(3):159-169.
[24]
Sørensen TIA, Ajslev TA, Ängquist L, et al. Comparison of associations of maternal peri-pregnancy and paternal anthropometrics with child anthropometrics from birth through age 7 y assessed in the Danish National Birth Cohort[J]. Am J Clin Nutr, 2016, 104(2):389-396.
